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| Reference : Duration of corneal anaesthesia following multiple doses and two concentrations of tetra... |
| Scientific journals : Article | |||
| Life sciences : Veterinary medicine & animal health | |||
| http://hdl.handle.net/2268/132423 | |||
| Duration of corneal anaesthesia following multiple doses and two concentrations of tetracaine hydrochloride eyedrops on the normal equine cornea | |
| English | |
Monclin, Sébastien  [Université de Liège - ULg > Département clinique des animaux de compagnie et des équidés > Pathologie médicale des petits animaux >] | |
| Farnir, Frédéric [Université de Liège - ULg > Département de productions animales > Biostatistiques et bioinformatique appliquées aux sc. vétér. >] | |
| Grauwels, Magda [Université de Liège - ULg > Département clinique des animaux de compagnie et des équidés > Département clinique des animaux de compagnie et des équidés >] | |
| Jan-2011 | |
| Equine Veterinary Journal | |
| Equine Veterinary Journal Ltd | |
| 43 | |
| 1 | |
| 69-73 | |
| Yes (verified by ORBi) | |
| International | |
| 0425-1644 | |
| Newmarket Suffolk | |
| United Kingdom | |
| [en] horse ; tetracaine hydrochloride ; cornea ; corneal sensitivity ; Cochet-Bonnet aesthesiometer | |
| [en] REASONS FOR PERFORMING STUDY:
There is a clinical impression that tetracaine hydrochloride (THCl) eyedrops is a suitable topical anaesthetic in horses. OBJECTIVE: To determine the duration of corneal anaesthesia following instillation of multiple doses and 2 concentrations of THCl in 10 healthy horses. METHODS: The corneal touch threshold (CTT) was determined, in both eyes, before (basal CTT) and after application of one drop of 0.5% THCl, 2 drops at a 1 min interval of 0.5% THCl or one drop of 1% THCl. CTT was measured in mm every 5 min until complete recovery of the basal CTT. Treatments were separated by an interval of at least one week. RESULTS: Corneal sensitivity was significantly reduced from baseline values for 30, 60 and 50 min after application of one drop of 0.5% THCl, 2 drops of 0.5% THCl and one drop of 1% THCl, respectively. Mean maximal anaesthetic effects, corresponding to a CTT of 0 mm, lasted 5.5, 16 and 15.25 min and maximal anaesthetic effect was present in 55, 90 and 80% of eyes, 5 min after application of one drop of 0.5% THCl, 2 drops of 0.5% THCl and one drop of 1% THCl, respectively. CONCLUSIONS: The application of a second drop or the use of more concentrated eyedrops significantly increases duration of both anaesthesia and maximal anaesthetic effect. POTENTIAL RELEVANCE: Duration of corneal anaesthesia following tetracaine instillation was established enabling a better use when performing diagnostic and therapeutic procedures. Comparison of tetracaine with other ocular anaesthetics needs to be published in the future. | |
| http://hdl.handle.net/2268/132423 |
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