Reference : Impaired effective cortical connectivity in vegetative state : Preliminary investigat...
Scientific journals : Article
Social & behavioral sciences, psychology : Neurosciences & behavior
http://hdl.handle.net/2268/13242
Impaired effective cortical connectivity in vegetative state : Preliminary investigation using PET
English
Laureys, Steven mailto [Université de Liège - ULg > > Centre de recherches du cyclotron]
Goldman, Serge [Université Libre de Bruxelles - ULB > > > > > >]
Phillips, Christophe mailto [Université de Liège - ULg > > Centre de recherches du cyclotron >]
van Bogaert, Patrick [> > > >]
Aerts, Joël mailto [Université de Liège - ULg > > Centre de recherches du cyclotron >]
Luxen, André mailto [Université de Liège - ULg > Centre de Recherches du Cyclotron - Département de chimie (sciences) > Chimie organique de synthèse > >]
Franck, Georges [Université de Liège - ULg > > Relations académiques et scientifiques (Médecine) >]
Maquet, Pierre mailto [Université de Liège - ULg > > Centre de recherches du cyclotron]
Apr-1999
Neuroimage
Academic Press Inc Elsevier Science
9
4
377-382
Yes (verified by ORBi)
International
1053-8119
San Diego
[en] Vegetative state
[en] Vegetative state (VS) is a condition of abolished awareness with persistence of arousal. Awareness is part of consciousness, which itself is thought to represent an emergent property of cerebral neural networks. Our hypothesis was that part of the neural correlate underlying VS is an altered connectivity, especially between the associative cortices. We assessed regional cerebral glucose metabolism (rCMRGlu) and effective cortical connectivity in four patients in VS by means of statistical parametric mapping and [F-18]fluorodeoxyglucose-positron emission tomography. Our data showed a common pattern of impaired rCMRGlu in the prefrontal, premotor, and parietotemporal association areas and posterior cingulate cortex/precuneus in VS. In a next step, we demonstrated that in VS patients various prefrontal and premotor areas have in common that they are less tightly connected with the posterior cingulate cortex than in normal controls. These results provide a strong argument for an alteration of cortical connectivity in VS patients. (C) 1999 Academic Press.
Fonds de la Recherche Scientifique (Communauté française de Belgique) - F.R.S.-FNRS ; The Queen Elisabeth Medical Foundation
http://hdl.handle.net/2268/13242
10.1006/nimg.1998.0414
http://www.elsevier.com/wps/find/journaldescription.cws_home/622925/description#description

File(s) associated to this reference

Fulltext file(s):

FileCommentaryVersionSizeAccess
Open access
LAUREYS_S_1999_Neuroimage_9_4_377.pdfNo commentaryAuthor postprint274.2 kBView/Open

Bookmark and Share SFX Query

All documents in ORBi are protected by a user license.