Doctoral thesis (Dissertations and theses)
Tailor-made degradable copolymers for the design of advanced drug delivery systems
Cajot, Sébastien
2012
 

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Keywords :
ring-opening polymerization (ROP); biomaterial; nanomedicine
Abstract :
[en] Over the last decades, polymer micelles have attracted an increasing interest in drug pharmaceutical research because they could be used as efficient drug delivery systems. The goal of this thesis was centered on the design of new smart nanocarriers and more particularly on the basis of reversibly redox-cross-linked polymer micelles. The first part of that work was dedicated to the synthesis of new macromolecular architectures associating biodegradable hydrophobic polymers such as polyester (e.g. PCL), polycarbonate (e.g. PTMC) or also polyphosphate (e.g. PBODOP) and the water soluble poly(ethylene oxide) (PEO) frequently used due to its biocompatible properties. Well-defined block copolymers have been synthesized by ring-opening polymerization. The second part of that work focused on the cross-linking of the hydrophobic block in order to obtain well stabilized micelles. The copolymerization of α-chloro-ε-caprolactone (αClεCL) allows to easy functionalize the hydrophobic block in order to reversibly cross-link the future micelle core by the addition of a disulfide bearing cross-linker. The self assembly of theses copolymers and redox-dependent micellization behaviours have been studied by diffusion light scattering and transmission electronic microscopy. Finally, the potential of these redox-sensitive micelles as active drug delivery system has been analysed by investigating their stealthy behaviours using the complement activation (CH50) test, their cytotoxicity, their cellular internalization and also the redox-sensitive profile of a hydrophobic dye.
Research center :
Center for Education and Research on Macromolecules (CERM)
Disciplines :
Chemistry
Author, co-author :
Cajot, Sébastien ;  Université de Liège - ULiège > Department of Chemistry > Center for Education and Research on Macromolecules (CERM)
Language :
English
Title :
Tailor-made degradable copolymers for the design of advanced drug delivery systems
Alternative titles :
[fr] Copolymères biodégradables sur mesure pour la conception de systèmes avancés d'administration des médicaments
Defense date :
29 August 2012
Institution :
ULiège - Université de Liège
Degree :
Docteur en sciences
Promotor :
Jérôme, Christine  ;  Université de Liège - ULiège > Complex and Entangled Systems from Atoms to Materials (CESAM)
Funders :
FRIA - Fonds pour la Formation à la Recherche dans l'Industrie et dans l'Agriculture [BE]
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since 16 October 2012

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