The impact of model-based therapeutics on glucose control in an intensive care unit

Glucose control; Integral-based parameter identification; Intensive Care Unit; Model-based therapeutics; Biomedical applications; Computation speed; Forward simulation; Gradient descent; Integral method; Integral-based identification; Intensive care; Model-based; Modelling error; Non-linear regression; Parameter identification; Therapy control; Computer simulation; Drug therapy; Glucose; Intensive care units; Parameter estimation

Abstract :

[en] This paper investigates the impact of fast parameter identification methods, which do not require any forward simulations, on model-based glucose control, using retrospective data in the Christchurch Hospital Intensive Care Unit. The integral-based identification method has been previously clinically validated and extensively applied in a number of biomedical applications; and is a crucial element in the presented model-based therapeutics approach. Common non-linear regression and gradient descent approaches are too computationally intense and not suitable for the glucose control applications presented. The main focus in this paper is on better characterizing and understanding the importance of the integral in the formulation and the effect it has on model-based drug therapy control. As a comparison, a potentially more natural derivative formulation which has the same computation speed advantages is investigated, and is shown to go unstable with respect to modelling error which is always present clinically. The integral method remains robust. © 2009 Springer Berlin Heidelberg.

Disciplines :

Engineering, computing & technology: Multidisciplinary, general & others

Author, co-author :

Hann, C. E.; Centre of Bio-Engineering, Department of Mechanical Engineering, University of Canterbury, Christchurch, New Zealand

Chase, J. G.; Centre of Bio-Engineering, Department of Mechanical Engineering, University of Canterbury, Christchurch, New Zealand

Desaive, Thomas ; Université de Liège - ULiège > Département d'astrophys., géophysique et océanographie (AGO) > Thermodynamique des phénomènes irréversibles

Ypma, M. F.; Control Systems Technology Group, Department of Mechanical Engineering, Eindhoven University of Technology, Netherlands

Elfring, J.; Control Systems Technology Group, Department of Mechanical Engineering, Eindhoven University of Technology, Netherlands

Shaw, G. M.; Department of Intensive Care, Christchurch Hospital, Christchurch, New Zealand

Language :

English

Title :

The impact of model-based therapeutics on glucose control in an intensive care unit

Publication date :

2008

Event name :

4th European Conference of the International Federation for Medical and Biological Engineering, ECIFMBE 2008

Event date :

23 November 2008 through 27 November 2008

Audience :

International

Journal title :

IFMBE Proceedings

ISSN :

1680-0737

Volume :

Pages :

1570-1573

Peer reviewed :

Peer reviewed

Commentary :

81647 9783540892076

Available on ORBi :

since 15 October 2012

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Bibliography

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