Probing command following in patients with disorders of consciousness using a brain-computer interface.

[en] OBJECTIVE: To determine if brain-computer interfaces (BCIs) could serve as supportive tools for detecting consciousness in patients with disorders of consciousness by detecting response to command and communication. METHODS: We tested a 4-choice auditory oddball EEG-BCI paradigm on 16 healthy subjects and 18 patients in a vegetative state/unresponsive wakefulness syndrome, in a minimally conscious state (MCS), and in locked-in syndrome (LIS). Subjects were exposed to 4 training trials and 10 -12 questions. RESULTS: Thirteen healthy subjects and one LIS patient were able to communicate using the BCI. Four of those did not present with a P3. One MCS patient showed command following with the BCI while no behavioral response could be detected at bedside. All other patients did not show any response to command and could not communicate with the BCI. CONCLUSION: The present study provides evidence that EEG based BCI can detect command following in patients with altered states of consciousness and functional communication in patients with locked-in syndrome. However, BCI approaches have to be simplified to increase sensitivity. SIGNIFICANCE: For some patients without any clinical sign of consciousness, a BCI might bear the potential to employ a "yes-no" spelling device offering the hope of functional interactive communication.

Research center :

GIGA CRC (Cyclotron Research Center) In vivo Imaging-Aging & Memory - ULiège

Disciplines :

Neurology

Author, co-author :

Lule, Dorothee ^✱

Noirhomme, Quentin ^✱; Université de Liège - ULiège > Centre de recherches du cyclotron

Kleih, Sonja C.

Chatelle, Camille ; Université de Liège - ULiège > Centre de recherches du cyclotron

Halder, Sebastian

Demertzi, Athina ; Université de Liège > Centre de recherches du cyclotron

Bruno, Marie-Aurélie ; Université de Liège - ULiège > Centre de recherches du cyclotron

Gosseries, Olivia ; Université de Liège - ULiège > Centre de recherches du cyclotron

Vanhaudenhuyse, Audrey ; Université de Liège - ULiège > Centre de recherches du cyclotron

Schnakers, Caroline ; Université de Liège - ULiège > Centre de recherches du cyclotron

More authors (4 more)

^✱ These authors have contributed equally to this work.

Language :

English

Title :

Probing command following in patients with disorders of consciousness using a brain-computer interface.

Publication date :

2013

Journal title :

Clinical Neurophysiology

ISSN :

1388-2457

eISSN :

1872-8952

Publisher :

Elsevier, Netherlands

Volume :

124

Issue :

Pages :

101-6

Peer reviewed :

Peer Reviewed verified by ORBi

European Projects :

FP7 - 247919 - DECODER - Deployment of Brain-Computer Interfaces for the Detection of Consciousness in Non-Responsive Patients

Funders :

CE - Commission Européenne [BE]

Commentary :

Available on ORBi :

since 11 October 2012

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