Reference : Mesenchymal stem cells and neural crest stem cells from adult bone marrow: characterizat...
Scientific journals : Article
Life sciences : Biochemistry, biophysics & molecular biology
http://hdl.handle.net/2268/131874
Mesenchymal stem cells and neural crest stem cells from adult bone marrow: characterization of their surprising similarities and differences.
English
Wislet, Sabine mailto [Université de Liège - ULg > Département des sciences biomédicales et précliniques > Biochimie et physiologie générales, et biochimie humaine >]
Laudet, Emerence mailto [Université de Liège - ULg > > GIGA - Neurosciences >]
Neirinckx, Virginie mailto [Université de Liège - ULg > Département des sciences biomédicales et précliniques > Histologie >]
Alix, Philippe [Université de Liège - ULg > Département des sciences biomédicales et précliniques > Pharmacologie >]
Leprince, Pierre mailto [Université de Liège - ULg > > GIGA - Neurosciences >]
glejzer, Aneta []
Poulet, Christophe [Université de Liège - ULg > Département des sciences biomédicales et précliniques > GIGA-R : Génétique humaine >]
Hennuy, Benoît mailto [Université de Liège - ULg > > GIGA-Management : Plate-forme transcriptomique >]
Sommer, Lukas []
Shakhova, Olga []
Rogister, Bernard mailto [Université de Liège - ULg > Département des sciences biomédicales et précliniques > Biochimie et physiologie générales, et biochimie humaine >]
Aug-2012
Cellular and Molecular Life Sciences : CMLS
Birkhäuser
69
15
2593-2608
Yes (verified by ORBi)
International
1420-682X
1420-9071
Basel
Switzerland
[en] The generation of neuronal cells from stem cells obtained from adult bone marrow is of significant clinical interest in order to design new cell therapy protocols for several neurological disorders. The recent identification in adult bone marrow of stem cells derived from the neural crest stem cells (NCSC) might explain the neuronal phenotypic plasticity shown by bone marrow cells. However, little information is available about the nature of these cells compared to mesenchymal stem cells (MSC), including their similarities and differences. In this paper, using transcriptomic as well as proteomic technologies, we compared NCSC to MSC and stromal nestin-positive cells, all of them isolated from adult bone marrow. We demonstrated that the nestin-positive cell population, which was the first to be described as able to differentiate into functional neurons, was a mixed population of NCSC and MSC. More interestingly, we demonstrated that MSC shared with NCSC the same ability to truly differentiate into Tuj1-positive cells when co-cultivated with paraformaldehyde-fixed cerebellar granule neurons. Altogether, those results suggest that both NCSC and MSC can be considered as important tools for cellular therapies in order to replace neurons in various neurological diseases.
Researchers
http://hdl.handle.net/2268/131874
http://www.ncbi.nlm.nih.gov+22349262

File(s) associated to this reference

Fulltext file(s):

FileCommentaryVersionSizeAccess
Restricted access
CMLS 2012.pdfPublisher postprint1.36 MBRequest copy

Bookmark and Share SFX Query

All documents in ORBi are protected by a user license.