Reference : Immunology in the clinic review series. Focus on type 1 diabetes and virus: enterovirus,...
Scientific journals : Article
Human health sciences : Endocrinology, metabolism & nutrition
Human health sciences : Immunology & infectious disease
http://hdl.handle.net/2268/131622
Immunology in the clinic review series. Focus on type 1 diabetes and virus: enterovirus, thymus and type 1 diabetes pathogenesis
English
Jaïdane, H. [Université Lille 2 CHRU > Laboratoire de Virologie EA3610 > > >]
Sane, F. [Université de Lille 2 CHRU > Laboratoire de Virologie EA3610 > > >]
Hiar, R. [Université de Lille 2 CHRU > Laboratoire de Virologie EA 3610 > > >]
Goffard, A. [Université de Lille 2 CHRU > Laboratoire de Virologie EA3610 > > >]
Gharbi, J. [Université de Monastir > Faculté de Pharmacie > Laboratoire des Maladies Transmissibles > >]
Geenen, Vincent mailto [Université de Liège - ULg > > Centre d'immunologie >]
Hober, Didier [Université de Lille 2 CHRU > Laboratoire de Virologie EA3610 > > >]
2012
Clinical & Experimental Immunology
Blackwell Publishing
168
39-46
Yes (verified by ORBi)
International
0009-9104
1365-2249
Oxford
United Kingdom
[en] Type 1 diabetes ; Thymus ; Coxsackievirus
[en] Thymus dysfunction, especially immune suppression, is frequently associated
with various virus infections.Whether viruses may disturb the thymus function
and play a role in the pathogenesis of autoimmune diseases is an open
issue. Enteroviruses, especially Coxsackievirus B4 (CV-B4), have been largely
suggested as potential inducers or aggravating factors of type 1 diabetes
(T1D) pathogenesis in genetically predisposed individuals. Several pathogenic
mechanisms of enterovirus-induced T1D have been suggested. One of
these mechanisms is the impairment of central self-tolerance due to viral
infections. Coxsackievirus-B4 is able to infect murine thymus in vitro and in
vivo and to infect human thymus in vitro. Thymic epithelial cells and thymocytes
are targets of infection with this virus, and several abnormalities,
especially disturbance of maturation/differentiation processes, were
observed.Altogether, these data suggest that CV-B infection of thymus may be
involved in the pathogenesis of T1D. Further investigations are needed to
explore this hypothesis.
GIGA - I3 Centre d'Immunologie
Fonds de la Recherche Scientifique (Communauté française de Belgique) - F.R.S.-FNRS
Researchers ; Professionals
http://hdl.handle.net/2268/131622
10.1111/j.1365-2249.2011.04558.x

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