ORBi: Jaïdane H. - Immunology in the clinic review series. Focus on type 1 diabetes and virus: enterovirus, thymus and type 1 diabetes pathogenesis

Reference : Immunology in the clinic review series. Focus on type 1 diabetes and virus: enterovirus,...


	Document type :	Scientific journals : Article
	Discipline(s) :	Human health sciences : Endocrinology, metabolism & nutrition Human health sciences : Immunology & infectious disease
	To cite this reference:	http://hdl.handle.net/2268/131622

Title :	Immunology in the clinic review series. Focus on type 1 diabetes and virus: enterovirus, thymus and type 1 diabetes pathogenesis
Language :	English
Author, co-author :	Jaïdane, H. [Université Lille 2 CHRU > Laboratoire de Virologie EA3610 > > >]
	Sane, F. [Université de Lille 2 CHRU > Laboratoire de Virologie EA3610 > > >]
	Hiar, R. [Université de Lille 2 CHRU > Laboratoire de Virologie EA 3610 > > >]
	Goffard, A. [Université de Lille 2 CHRU > Laboratoire de Virologie EA3610 > > >]
	Gharbi, J. [Université de Monastir > Faculté de Pharmacie > Laboratoire des Maladies Transmissibles > >]
	Geenen, Vincent [Université de Liège - ULg > > Centre d'immunologie >]
	Hober, Didier [Université de Lille 2 CHRU > Laboratoire de Virologie EA3610 > > >]
Publication date :	2012
Journal title :	Clinical & Experimental Immunology
Publisher :	Blackwell Publishing
Volume :	168
Pages :	39-46
Audience :	International
ISSN :	0009-9104
e-ISSN :	1365-2249
City :	Oxford
Country :	United Kingdom
Keywords :	[en] Type 1 diabetes ; Thymus ; Coxsackievirus
Abstract :	[en] Thymus dysfunction, especially immune suppression, is frequently associated with various virus infections.Whether viruses may disturb the thymus function and play a role in the pathogenesis of autoimmune diseases is an open issue. Enteroviruses, especially Coxsackievirus B4 (CV-B4), have been largely suggested as potential inducers or aggravating factors of type 1 diabetes (T1D) pathogenesis in genetically predisposed individuals. Several pathogenic mechanisms of enterovirus-induced T1D have been suggested. One of these mechanisms is the impairment of central self-tolerance due to viral infections. Coxsackievirus-B4 is able to infect murine thymus in vitro and in vivo and to infect human thymus in vitro. Thymic epithelial cells and thymocytes are targets of infection with this virus, and several abnormalities, especially disturbance of maturation/differentiation processes, were observed.Altogether, these data suggest that CV-B infection of thymus may be involved in the pathogenesis of T1D. Further investigations are needed to explore this hypothesis.
Research units :	GIGA - I3 Centre d'Immunologie
Funders :	Fonds de la Recherche Scientifique (Communauté française de Belgique) - F.R.S.-FNRS
Target :	Researchers ; Professionals
Permalink :	http://hdl.handle.net/2268/131622
DOI :	10.1111/j.1365-2249.2011.04558.x

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