Reference : Du nouveau à l'interface materno-foetale: rôle du couple hCG/récepteur LH-hCG dans l'imp...
Scientific journals : Article
Human health sciences : Reproductive medicine (gynecology, andrology, obstetrics)
Du nouveau à l'interface materno-foetale: rôle du couple hCG/récepteur LH-hCG dans l'implantation embryonnaire
[en] What's new at the maternal-foetal interface: role of the hCG/LH-hCG receptor couple during embryo implantation
PERRIER d'HAUTERIVE, Sophie [Université de Liège - ULg > > Gynécologie-Obstétrique CHR >]
Charlet, Jeanne de Chantal [Université de Liège - ULg > > Endocrinologie clinique >]
Dubois, Michel [Université de Liège - ULg > > Gynécologie-Obstétrique CHR >]
Foidart, Jean-Michel mailto [Université de Liège - ULg > Département des sciences cliniques > Gynécologie - Obstétrique - Labo de biologie des tumeurs et du développement >]
Geenen, Vincent mailto [Université de Liège - ULg > > Centre d'immunologie - Embryologie >]
Revue Médicale de Liège
Hopital de Baviere
Yes (verified by ORBi)
[en] hCG/LH-hCGR ; Implantation ; Embryo
[en] Implantation of the embryo into the maternal endometrium represents a unique biological process, combining an immunological (tolerance of an allograft) and biological (adhesion of two epitheliums) paradox. The success of implantation depends on a receptive endometrium, a functionally normal blastocyst and a synchronized cross-talk between embryonic and maternal tissues. Though sexual steroids control the process, a cascade of growth factors or cytokines are the prime paracrine mediators of the dialogue at the maternal-embryonic interface. HCG is one of the molecules most precociously produced by the embryo and is the most specific marker of its presence. HCG is a luteotropic factor which relays the inadequate support provided by the reduced rates of LH, but also influences the pregnancy on a paracrine mode by a local action on implantation process, probably by interacting with its receptor, the LH/hCG-R that we have evidenced on endometrial epithelium. We demonstrate that embryo actively participate into its implantation, tolerance and placentation.

File(s) associated to this reference

Fulltext file(s):

Open access
Perrier d'Hauterive S RML 2006.pdfPublisher postprint706.03 kBView/Open

Bookmark and Share SFX Query

All documents in ORBi are protected by a user license.