[en] Implantation of the embryo into the maternal endometrium represents a unique biological process, combining an immunological (tolerance of an allograft) and biological (adhesion of two epitheliums) paradox. The success of implantation depends on a receptive endometrium, a functionally normal blastocyst and a synchronized cross-talk between embryonic and maternal tissues. Though sexual steroids control the process, a cascade of growth factors or cytokines are the prime paracrine mediators of the dialogue at the maternal-embryonic interface. HCG is one of the molecules most precociously produced by the embryo and is the most specific marker of its presence. HCG is a luteotropic factor which relays the inadequate support provided by the reduced rates of LH, but also influences the pregnancy on a paracrine mode by a local action on implantation process, probably by interacting with its receptor, the LH/hCG-R that we have evidenced on endometrial epithelium. We demonstrate that embryo actively participate into its implantation, tolerance and placentation.
Disciplines :
Reproductive medicine (gynecology, andrology, obstetrics)
Dubois, Michel ; Université de Liège - ULiège > Gynécologie-Obstétrique CHR
Foidart, Jean-Michel ; Université de Liège - ULiège > Département des sciences cliniques > Gynécologie - Obstétrique - Labo de biologie des tumeurs et du développement
Geenen, Vincent ; Université de Liège - ULiège > Centre d'immunologie - Embryologie
Language :
English
Title :
Du nouveau à l'interface materno-foetale: rôle du couple hCG/récepteur LH-hCG dans l'implantation embryonnaire
Alternative titles :
[en] What's new at the maternal-foetal interface: role of the hCG/LH-hCG receptor couple during embryo implantation
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