Antioxidant Therapy in Intensive Care

[en] PURPOSE OF REVIEW: This review intends to summarize the recent findings regarding the presence of increased oxidative stress in critically ill patients and its potential pathophysiologic role, as well as the results of recent clinical trials of antioxidant therapies. RECENT FINDINGS: Several lines of evidence confirm the increase in oxidative stress during critical illness. The oxidative damage to cells and tissues eventually contributes to organ failure. Prophylactic administration of antioxidant vitamins or glutamine, incorporated in the nutritional support or given as separate medications, efficiently attenuates the oxidative stress and in some studies improves the outcome of critically ill patients. Few data on the effects of N-acetylcysteine or trace elements have been published during the last two years. SUMMARY: Patients at risk of organ failure could benefit from the early adjunction of antioxidant treatment, including vitamins and glutamine.

Disciplines :

Anesthesia & intensive care

Author, co-author :

Lovat, R.

Preiser, Jean-Charles ; Université de Liège - ULiège > Services généraux (Faculté de médecine) > Relations académiques et scientifiques (Médecine)

Language :

English

Title :

Antioxidant Therapy in Intensive Care

Publication date :

August 2003

Journal title :

Current Opinion in Critical Care

ISSN :

1070-5295

eISSN :

1531-7072

Publisher :

Lippincott Williams & Wilkins, United States - Maryland

Volume :

Issue :

Pages :

266-70

Available on ORBi :

since 25 September 2012

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Bibliography

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