Reference : Nucleic acid sensing at the interface between innate and adaptive immunity in vaccination
Scientific journals : Article
Human health sciences : Immunology & infectious disease
http://hdl.handle.net/2268/130964
Nucleic acid sensing at the interface between innate and adaptive immunity in vaccination
English
Desmet, Christophe mailto [Université de Liège - ULg > Département de sciences fonctionnelles > Physiologie >]
Ishii, Ken J. [> >]
2012
Nature Reviews. Immunology
12
7
479-491
Yes (verified by ORBi)
International
1474-1733
1474-1741
[en] vaccination ; adjuvant ; nucleic acid
[en] The demand is currently high for new vaccination strategies, particularly to help combat problematic intracellular pathogens, such as HIV and malarial parasites. In the past decade, the identification of host receptors that recognize pathogen-derived nucleic acids has revealed an essential role for nucleic acid sensing in the triggering of immunity to intracellular pathogens. This Review first addresses our current understanding of the nucleic acid-sensing
immune machinery. We then explain how the study of nucleic acid-sensing mechanisms not
only has revealed their central role in driving the responses mediated by many current vaccines, but is also revealing how they could be harnessed for the design of new vaccines.
http://hdl.handle.net/2268/130964
http://dx.doi.org/10.1038/nri3247

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