|Reference : Nucleic acid sensing at the interface between innate and adaptive immunity in vaccination|
|Scientific journals : Article|
|Human health sciences : Immunology & infectious disease|
|Nucleic acid sensing at the interface between innate and adaptive immunity in vaccination|
|Desmet, Christophe [Université de Liège - ULg > Département de sciences fonctionnelles > Physiologie >]|
|Ishii, Ken J. [> >]|
|Nature Reviews. Immunology|
|Yes (verified by ORBi)|
|[en] vaccination ; adjuvant ; nucleic acid|
|[en] The demand is currently high for new vaccination strategies, particularly to help combat problematic intracellular pathogens, such as HIV and malarial parasites. In the past decade, the identification of host receptors that recognize pathogen-derived nucleic acids has revealed an essential role for nucleic acid sensing in the triggering of immunity to intracellular pathogens. This Review first addresses our current understanding of the nucleic acid-sensing
immune machinery. We then explain how the study of nucleic acid-sensing mechanisms not
only has revealed their central role in driving the responses mediated by many current vaccines, but is also revealing how they could be harnessed for the design of new vaccines.
|File(s) associated to this reference|
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