Reference : Rapid control of male typical behaviors by brain-derived estrogens
Scientific journals : Article
Social & behavioral sciences, psychology : Neurosciences & behavior
http://hdl.handle.net/2268/130613
Rapid control of male typical behaviors by brain-derived estrogens
English
Cornil, Charlotte mailto [Université de Liège - ULg > Département des sciences biomédicales et précliniques > Biologie de la différenciation sexuelle du cerveau >]
Ball, Gregory F [> >]
Balthazart, Jacques mailto [Université de Liège - ULg > Département des sciences biomédicales et précliniques > Biologie de la différenciation sexuelle du cerveau >]
2012
Frontiers in Neuroendocrinology
Academic Press
Yes (verified by ORBi)
International
0091-3022
1095-6808
Orlando
FL
[en] Beside their genomic mode of action, estrogens also activate a variety of cellular signaling pathways through non-genomic mechanisms. Until recently, little was known regarding the functional significance of such actions in males and the mechanism that control local estrogen concentration with a spatial and time resolution compatible with these non-genomic actions had rarely been examined. Here, we review evidence that estrogens rapidly modulate a variety of behaviors in male vertebrates. Then, we present in vitro work supporting the existence of a control mechanism of local brain estrogen synthesis by aromatase along with in vivo evidence that rapid changes in aromatase activity also occur in a region-specific manner in response to changes in the social or environmental context. Finally, we suggest that the brain estrogen provision may also play a significant role in females. Together these data bolster the hypothesis that brain-derived estrogens should be considered as neuromodulators.
Giga-Neurosciences
National Institutes of Health - NIH ; Fonds de la Recherche Scientifique (Communauté française de Belgique) - F.R.S.-FNRS ; ULg
http://hdl.handle.net/2268/130613
10.1016/j.yfrne.2012.08.003
http://www.sciencedirect.com/science/article/pii/S0091302212000350?v=s5

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