Reference : Differential expression of two somatostatin genes during zebrafish embryonic development
Scientific journals : Article
Life sciences : Biochemistry, biophysics & molecular biology
http://hdl.handle.net/2268/13050
Differential expression of two somatostatin genes during zebrafish embryonic development
English
Devos, Nathalie [ > > ]
Deflorian, Gianluca [Università di Padova > Dipartimento di Biologia > > >]
Biemar, Frédéric [> > > >]
Bortolussi, Marino [Università di Padova > Dipartimento di Biologia > > >]
Martial, Joseph mailto [Université de Liège - ULg > Département des sciences de la vie > GIGA-R : Biologie et génétique moléculaire >]
Peers, Bernard mailto [Université de Liège - ULg > Département des sciences de la vie > GIGA-R : Biologie et génétique moléculaire >]
Argenton, Francesco [Università di Padova > Dipartimento di Biologia > > >]
2002
Mechanisms of Development
Elsevier
115
1-2
133-7
Yes (verified by ORBi)
0925-4773
1872-6356
Limerick
Ireland
[en] Amino Acid Sequence ; Animals ; Base Sequence ; Brain/embryology/metabolism ; Central Nervous System/embryology/*metabolism ; DNA, Complementary ; *Gene Expression ; Gene Expression Profiling ; Humans ; Molecular Sequence Data ; Pancreas/embryology/*metabolism ; Phylogeny ; Protein Precursors/classification/*genetics ; Proteins/genetics ; *Repressor Proteins ; Sequence Homology, Amino Acid ; Somatostatin/classification/*genetics ; Zebrafish/embryology/*genetics ; Zebrafish Proteins
[en] We have identified the cDNAs of two new zebrafish preprosomatostatins, PPSS1 and PPSS3, in addition to the previously cloned PPSS2 (Argenton et al., 1999). PPSS1 is the orthologue of mammalian PPSSs, with a conserved C-terminal SS-14 sequence, PPSS2 is a divergent SS precursor and PPSS3 is a cortistatin-like prohormone. Using whole-mount in situ hybridisation, we have analysed the expression of PPSS1 and PPSS2 in zebrafish embryos up to 5 days post fertilisation. PPSS1 was expressed in the developing pancreas and central nervous system (CNS), whereas PPSS2 expression was exclusively pancreatic. In the CNS, PPSS1 was detected in several areas, in particular in the vagal motor nucleus and in cells that pioneer the tract of the postoptic commissure. PPSS1 was also expressed transiently in the telencephalon and spinal motor neurons. In all areas but the telencephalon PPSS1 was coexpressed with islet-1.
http://hdl.handle.net/2268/13050
10.1016/S0925-4773(02)00082-5
http://www.sciencedirect.com/science?_ob=ArticleURL&_udi=B6T9H-45KSYDJ-2&_user=532038&_rdoc=1&_fmt=&_orig=search&_sort=d&view=c&_acct=C000026659&_version=1&_urlVersion=0&_userid=532038&md5=98cd547aa49b7df120eb49ec93a2517e
2002/06/07

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