Reference : Smart nanocarriers for pH-triggered targeting and release of hydrophobic drugs
Scientific journals : Article
Physical, chemical, mathematical & earth Sciences : Chemistry
Engineering, computing & technology : Materials science & engineering
http://hdl.handle.net/2268/130349
Smart nanocarriers for pH-triggered targeting and release of hydrophobic drugs
English
Cajot, Sébastien [University of Liège (ULg) > Department of Chemistry > Center for Education and Research on Macromolecules (CERM) > >]
Van Butsele, Kathy [University of Liège (ULg) > Department of Chemistry > Center for Education and Research on Macromolecules (CERM) > >]
Paillard, A. [University of Angers (France) > > INSERM > >]
Passirani, C. [University of Angers (France) > > INSERM > >]
Garcion, E. [University of Angers (France) > > INSERM > >]
Benoit, J.-P. [University of Angers (France) > > INSERM > >]
Jérôme, Christine mailto [University of Liège (ULg) > Department of Chemistry > Center for Education and Research on Macromolecules (CERM) > >]
Varshney, S. K. [Polymer Source, Dorval, Canada > > > >]
Dec-2012
Acta Biomaterialia
Elsevier Science
8
12
4215-4223
Yes (verified by ORBi)
International
1742-7061
Oxford
United Kingdom
[en] biomaterial ; nanomedicine ; self-assembly in solution ; stimuli responsive micelle ; pH-sensitive polymer
[en] The use of hybrid pH-sensitive micelles mainly based on the PEO129-P2VP43-PCL17 ABC miktoarm star copolymer as potential triggered drug delivery systems has been investigated. Co-micellization of this star copolymer with a second copolymer labeled by a targeting ligand, i.e. biotin, on the pH sensitive block (poly-2-vinylpyridine, P2VP) has been considered here in order to impart possible active targeting of the tumor cells. Two architectures have been studied for these labeled copolymers, i.e. a miktoarm star or a linear ABC terpolymer and the respective hybrid micelles have been compared in terms of cytotoxicity (cells viability) and cellular uptake (by using fluorescent dye loaded micelles). Finally, the triggered drug release in the cytosol of tumor cells was investigated by studying on one hand the lysosomal integrity after internalization and on the other hand the release profile in function of the pH.
Center for Education and Research on Macromolecules (CERM)
Politique Scientifique Fédérale (Belgique) = Belgian Federal Science Policy ; Fonds pour la formation à la Recherche dans l'Industrie et dans l'Agriculture (Communauté française de Belgique) - FRIA ; The French "Ligue Nationale Contre le Cancer" ; The CGRI-FNRS-Inserm cooperation program
Researchers
http://hdl.handle.net/2268/130349
10.1016/j.actbio.2012.08.049
http://www.sciencedirect.com/science/article/pii/S1742706112004266

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