Article (Scientific journals)
Abnormal vascular architecture at the placental-maternal interface in placenta increta
CHANTRAINE, Frédéric; Blacher, Silvia; Berndt, Sarah et al.
2012In American Journal of Obstetrics and Gynecology, 207 (3), p. 188.e1-9
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Keywords :
placenta increta; placental bed; vessel architecture; virtual imaging
Abstract :
[en] Objective The objective of the study was to characterize the vascular architecture at the placental-maternal interface in pregnancies complicated by placenta increta and normal pregnancies. Study Design Vessel numbers and cross-section area density and spatial and area distributions in 13 placenta-increta placental beds were compared with 9 normal placental beds using computer-assisted image analysis of whole-slide CD31 immunolabeled sections. Results The total areas occupied by vessels in normal and placenta-increta placental beds were comparable, but vessels were significantly sparser and larger in the latter. Moreover, placenta-increta–vessel distributions (area and distance from the placental–myometrial junction) were more heterogeneous. Conclusion Size and spatial organization of the placenta-increta vascular architecture at the placental-maternal interface differed from normal and might partially explain the severe hemorrhage observed during placenta-increta deliveries.
Disciplines :
Reproductive medicine (gynecology, andrology, obstetrics)
Author, co-author :
CHANTRAINE, Frédéric  ;  Centre Hospitalier Universitaire de Liège - CHU > Gynécologie-Obstétrique CHR
Blacher, Silvia ;  Université de Liège - ULiège > Département des sciences cliniques > Labo de biologie des tumeurs et du développement
Berndt, Sarah
Palacios-Jaraquemada, José
Sarioglu, Nanette
Nisolle, Michelle ;  Université de Liège - ULiège > Département des sciences cliniques > Gynécologie - Obstétrique
Braun, T
Munaut, Carine  ;  Université de Liège - ULiège > Département des sciences cliniques > Labo de biologie des tumeurs et du développement
Foidart, Jean-Michel ;  Université de Liège - ULiège > Département des sciences cliniques > Gynécologie - Obstétrique
Language :
English
Title :
Abnormal vascular architecture at the placental-maternal interface in placenta increta
Publication date :
2012
Journal title :
American Journal of Obstetrics and Gynecology
ISSN :
0002-9378
eISSN :
1097-6868
Publisher :
Mosby, St Louis, United States - Missouri
Volume :
207
Issue :
3
Pages :
188.e1-9
Peer reviewed :
Peer Reviewed verified by ORBi
Available on ORBi :
since 12 September 2012

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