ORBi: CHANTRAINE Frédéric - Abnormal vascular architecture at the placental-maternal interface in placenta increta

Reference : Abnormal vascular architecture at the placental-maternal interface in placenta increta


	Document type :	Scientific journals : Article
	Discipline(s) :	Human health sciences : Reproductive medicine (gynecology, andrology, obstetrics)
	To cite this reference:	http://hdl.handle.net/2268/130347

Title :	Abnormal vascular architecture at the placental-maternal interface in placenta increta
Language :	English
Author, co-author :	CHANTRAINE, Frédéric [Centre Hospitalier Universitaire de Liège - CHU > > Gynécologie-Obstétrique CHR >]
	Blacher, Silvia [Université de Liège - ULg > Département des sciences cliniques > Labo de biologie des tumeurs et du développement >]
	Berndt, Sarah []
	Palacios-Jaraquemada, José []
	Sarioglu, Nanette []
	Nisolle, Michelle [Université de Liège - ULg > Département des sciences cliniques > Gynécologie - Obstétrique >]
	Braun, T []
	Munaut, Carine [Université de Liège - ULg > Département des sciences cliniques > Labo de biologie des tumeurs et du développement >]
	Foidart, Jean-Michel [Université de Liège - ULg > Département des sciences cliniques > Gynécologie - Obstétrique >]
Publication date :	2012
Journal title :	American Journal of Obstetrics and Gynecology
Publisher :	Mosby
Volume :	207
Issue/season :	3
Pages :	188.e1-9
Audience :	International
ISSN :	0002-9378
e-ISSN :	1097-6868
City :	St Louis
Country :	MO
Keywords :	[en] placenta increta ; placental bed ; vessel architecture ; virtual imaging
Abstract :	[en] Objective The objective of the study was to characterize the vascular architecture at the placental-maternal interface in pregnancies complicated by placenta increta and normal pregnancies. Study Design Vessel numbers and cross-section area density and spatial and area distributions in 13 placenta-increta placental beds were compared with 9 normal placental beds using computer-assisted image analysis of whole-slide CD31 immunolabeled sections. Results The total areas occupied by vessels in normal and placenta-increta placental beds were comparable, but vessels were significantly sparser and larger in the latter. Moreover, placenta-increta–vessel distributions (area and distance from the placental–myometrial junction) were more heterogeneous. Conclusion Size and spatial organization of the placenta-increta vascular architecture at the placental-maternal interface differed from normal and might partially explain the severe hemorrhage observed during placenta-increta deliveries.
Permalink :	http://hdl.handle.net/2268/130347
DOI :	10.1016/j.ajog.2012.06.083

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