Reference : Abnormal vascular architecture at the placental-maternal interface in placenta increta
Scientific journals : Article
Human health sciences : Reproductive medicine (gynecology, andrology, obstetrics)
http://hdl.handle.net/2268/130347
Abnormal vascular architecture at the placental-maternal interface in placenta increta
English
CHANTRAINE, Frédéric mailto [Centre Hospitalier Universitaire de Liège - CHU > > Gynécologie-Obstétrique CHR >]
Blacher, Silvia mailto [Université de Liège - ULg > Département des sciences cliniques > Labo de biologie des tumeurs et du développement >]
Berndt, Sarah []
Palacios-Jaraquemada, José []
Sarioglu, Nanette []
Nisolle, Michelle mailto [Université de Liège - ULg > Département des sciences cliniques > Gynécologie - Obstétrique >]
Braun, T []
Munaut, Carine mailto [Université de Liège - ULg > Département des sciences cliniques > Labo de biologie des tumeurs et du développement >]
Foidart, Jean-Michel mailto [Université de Liège - ULg > Département des sciences cliniques > Gynécologie - Obstétrique >]
2012
American Journal of Obstetrics and Gynecology
Mosby
207
3
188.e1-9
Yes (verified by ORBi)
International
0002-9378
1097-6868
St Louis
MO
[en] placenta increta ; placental bed ; vessel architecture ; virtual imaging
[en] Objective
The objective of the study was to characterize the vascular architecture at the placental-maternal interface in pregnancies complicated by placenta increta and normal pregnancies.

Study Design
Vessel numbers and cross-section area density and spatial and area distributions in 13 placenta-increta placental beds were compared with 9 normal placental beds using computer-assisted image analysis of whole-slide CD31 immunolabeled sections.

Results
The total areas occupied by vessels in normal and placenta-increta placental beds were comparable, but vessels were significantly sparser and larger in the latter. Moreover, placenta-increta–vessel distributions (area and distance from the placental–myometrial junction) were more heterogeneous.

Conclusion
Size and spatial organization of the placenta-increta vascular architecture at the placental-maternal interface differed from normal and might partially explain the severe hemorrhage observed during placenta-increta deliveries.
http://hdl.handle.net/2268/130347
10.1016/j.ajog.2012.06.083

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