ORBi: Bruyère Olivier - Relationships Between Changes in Bone Mineral Density or Bone Turnover Markers and Vertebral Fracture Incidence in Patients Treated with Bazedoxifene

Reference : Relationships Between Changes in Bone Mineral Density or Bone Turnover Markers and Verte...


	Document type :	Scientific journals : Article
	Discipline(s) :	Human health sciences : Public health, health care sciences & services Human health sciences : General & internal medicine
	To cite this reference:	http://hdl.handle.net/2268/130296

Title :	Relationships Between Changes in Bone Mineral Density or Bone Turnover Markers and Vertebral Fracture Incidence in Patients Treated with Bazedoxifene
Language :	English
Author, co-author :	Bruyère, Olivier [Université de Liège - ULg > Département des sciences de la santé publique > Santé publique, Epidémiologie et Economie de la santé >]
	Detilleux, Johann [Université de Liège - ULg > Département de productions animales > Génétique quantitative >]
	Chines, Arkadi []
	Reginster, Jean-Yves [Université de Liège - ULg > Département des sciences de la santé publique > Santé publique, Epidémiologie et Economie de la santé >]
Publication date :	Sep-2012
Journal title :	Calcified Tissue International
Publisher :	Springer Verlag
Volume :	91
Issue/season :	4
Pages :	244-9
Audience :	International
ISSN :	0171-967X
City :	New York
Country :	NY
Keywords :	[en] Bone turnover marker ; DEXA ; Fracture ; Bazedoxifene
Abstract :	[en] We analyzed the relationships between bone mineral density (BMD) or bone turnover marker (BTM) changes and vertebral fracture incidence in women treated with bazedoxifene using a post hoc analysis from a 3-year randomized, placebo-controlled study evaluating the effect of bazedoxifene (20 or 40 mg) on fracture risk reduction. BMD was assessed at baseline and every 6 months for 3 years. Osteocalcin and C-telopeptide of type I collagen were assessed at baseline and at 3, 12, and 36 months. Vertebral fractures were assessed with a semiquantitative visual assessment. Data were available for 5,244 women, of whom 3,476 were treated with bazedoxifene. Using a logistic regression analysis and the classical Li approach, the proportion of fracture incidence explained by BMD change after 3 years of bazedoxifene treatment was 29 % for the total hip and 44 % for the femoral neck. The proportion of treatment explained by lumbar BMD change could not be quantified accurately because of the significant interaction between treatment and change in BMD. With the same model, the 12-month BTM changes explained up to 29 % of the fracture risk reduction observed with the two forms of bazedoxifene. In women treated with bazedoxifene, changes in femoral neck BMD, hip BMD, or BTMs explained a moderate proportion of the fracture risk reduction observed during the 3 years of follow-up. However, BMD or BTM changes cannot be recommended for individual monitoring of women treated with bazedoxifene.
Permalink :	http://hdl.handle.net/2268/130296
DOI :	10.1007/s00223-012-9629-y

File(s) associated to this reference

Fulltext file(s):

	File	Commentary	Version	Size	Access
Restricted access	Relationships between changes in bone mineral density or bone turnover markers and vertebral fracture incidence ....pdf		Publisher postprint	168.34 kB	Request copy

All documents in ORBi are protected by a user license.

Dspace v1.5