Reference : Influence of sleep homeostasis and circadian rhythm on executive discriminative abili...
Scientific congresses and symposiums : Poster
Human health sciences : Neurology
Life sciences : Genetics & genetic processes
http://hdl.handle.net/2268/130263
Influence of sleep homeostasis and circadian rhythm on executive discriminative ability during a constant routine
English
Jaspar, Mathieu mailto [Université de Liège - ULg > Département de Psychologie : cognition et comportement; Centre de recherches du cyclotron; WELBIO, Belgium > Neuropsychologie > >]
Meyer, Christelle mailto [Université de Liège - ULg > > Centre de recherches du cyclotron; WELBIO, Belgium > >]
Muto, Vincenzo mailto [Université de Liège - ULg > Département de Psychologie > Centre de recherches du cyclotron; WELBIO, Belgium > >]
Shaffii, Anahita mailto [Université de Liège - ULg > > Centre de recherches du cyclotron >]
Chellappa, Sarah Laxhmi mailto [Université de Liège - ULg > > Centre de recherches du cyclotron >]
Vandewalle, Gilles mailto [Université de Liège - ULg > > Centre de recherches du cyclotron >]
Collette, Fabienne mailto [Université de Liège - ULg > Département de Psychologie : cognition et comportement > Neuropsychologie >]
Archer, Simon [Surrey Sleep Research Centre, Faculty of Health and Medical Sciences, University of Surrey, Guildford, UK > > > >]
Dijk, Derk-Jan [Surrey Sleep Research Centre, Faculty of Health and Medical Sciences, University of Surrey, Guildford, UK > > > >]
MAQUET, Pierre mailto [Centre Hospitalier Universitaire de Liège - CHU > > Neurologie Sart Tilman >]
Sep-2012
Yes
No
International
21st Congress of the European Sleep Research Society
4 - 8 September 2012
Paris
France
[en] Sleep ; gene PERIOD3 (PER3) ; circadian rhythms
[en] Introduction & Objectives
The human brain upholds cognitive performance throughout a waking day due to putative circadian (C) arousal signal which counteracts the increase in homeostatic (H) sleep pressure associated to the deterioration in brain efficiency. When wakefulness is extended into the circadian night, maintenance of cognitive performance is jeopardized . Some individuals are very vulnerable to the negative effects of sleep loss and circadian misalignment, whereas others are resilient. These individuals differences can be readily explained within the conceptual framework of the circadian and homeostatic regulation of performance but also by individual genetic differences and notably the PERIOD3 gene polymorphism.
In this experiment, we investigated the consequences of sleep deprivation on cognitive performance during a working memory task (3-back). Following the signal detection theory, the ability to discriminate target from non-target stimuli is estimated by d prime (d') and criterion (cr). Here we assessed whether d' and cr were modulated by the raising sleep need and the oscillatory circadian signal. We also tested whether the individual vulnerability to sleep loss predicted by the PERIOD3 gene polymorphism influences this cognitive modulation, which is also driven by the sleep/wake regulation.
Cyclotron Research Centre, University of Liège, Belgium
http://hdl.handle.net/2268/130263

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