Reference : Influence of sleep homeostasis and circadian rhythm on waking EEG oscillations during...
Scientific congresses and symposiums : Paper published in a journal
Human health sciences : Neurology
Life sciences : Genetics & genetic processes
http://hdl.handle.net/2268/130261
Influence of sleep homeostasis and circadian rhythm on waking EEG oscillations during a constant routine
English
Muto, Vincenzo mailto [Université de Liège - ULg > > Centre de recherches du cyclotron; Welbio, Belgium > > >]
Jaspar, Mathieu mailto [Université de Liège > Département de Psychologie > Ergonomie et intervention au travail >]
Meyer, C []
Shaffii, A []
Kussé, C []
Foret, A []
Chellappa []
Vandewalle, Gilles mailto [Université de Liège > > Centre de recherches du cyclotron >]
Collette, Fabienne mailto [Université de Liège > Département de Psychologie > Neuropsychologie >]
Archer, S [University of Surrey, Guildford, United Kingdom > Faculty of Health and Medical Sciences > > >]
Dijk, D [University of Surrey, Guildford, United Kingdom > Faculty of Health and Medical Sciences > > >]
Maquet, Pierre mailto [Université de Liège > Département des sciences cliniques > Neurologie >]
Sep-2012
Journal of Sleep Research
Blackwell Publishing
Yes (verified by ORBi)
No
International
0962-1105
1365-2869
Oxford
United Kingdom
21st Congress of the European Sleep Research Society
4 - 8 September 2012
European Sleep Research Society
Paris
France
[en] Sleep ; gene PERIOD3 (PER3) ; circadian rhythms
[en] Human sleep and wake EEG oscillations are modulated by complex non-additive interaction between homeostatic and circadian processes. Quantitative analysis of EEG data, during extended wakefulness, indicate that its frequency-specificity is influenced by both factors, such that low-frequencies (<8Hz) increase with time spent awake, thus more homeostatically-driven, while alpha activity undergoes a clear circadian modulation.
Interindividual differences in sleep-wake regulation in young volunteers are associated with the variable-number tandem-repeat (VNTR) polymorphism in the coding region of the circadian clock gene PERIOD3 (PER3). Individuals homozygous for the longer allele of PER3 (PER3 5/5) were reported to generate more slow wave activity during NREM sleep and theta activity during wakefulness, relative to individuals with the shorter allele (PER3 4/4). However, the phase and amplitude of circadian markers do not differ between these genotypes.
Here we tested the hypothesis if fluctuations in the dynamics of waking EEG frequency-specificity are modulated by a polymorphism in the clock gene PER3, under 42h of sustained wakefulness.
Cyclotron Research Centre, University of Liège, Belgium
http://hdl.handle.net/2268/130261

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