|Reference : Influence of sleep homeostasis and circadian rhythm on waking EEG oscillations during...|
|Scientific congresses and symposiums : Paper published in a journal|
|Life sciences : Genetics & genetic processes|
Human health sciences : Neurology
|Influence of sleep homeostasis and circadian rhythm on waking EEG oscillations during a constant routine|
|Muto, Vincenzo [Université de Liège - ULg > > Centre de recherches du cyclotron; Welbio, Belgium > > >]|
|Jaspar, Mathieu [Université de Liège > Département de Psychologie > Ergonomie et intervention au travail >]|
|Meyer, C |
|Shaffii, A |
|Kussé, C |
|Foret, A |
|Vandewalle, Gilles [Université de Liège > > Centre de recherches du cyclotron >]|
|Collette, Fabienne [Université de Liège > Département de Psychologie > Neuropsychologie >]|
|Archer, S [University of Surrey, Guildford, United Kingdom > Faculty of Health and Medical Sciences > > >]|
|Dijk, D [University of Surrey, Guildford, United Kingdom > Faculty of Health and Medical Sciences > > >]|
|Maquet, Pierre [Université de Liège > Département des sciences cliniques > Neurologie >]|
|Journal of Sleep Research|
|Yes (verified by ORBi)|
|21st Congress of the European Sleep Research Society|
|4 - 8 September 2012|
|European Sleep Research Society|
|[en] Sleep ; gene PERIOD3 (PER3) ; circadian rhythms|
|[en] Human sleep and wake EEG oscillations are modulated by complex non-additive interaction between homeostatic and circadian processes. Quantitative analysis of EEG data, during extended wakefulness, indicate that its frequency-specificity is influenced by both factors, such that low-frequencies (<8Hz) increase with time spent awake, thus more homeostatically-driven, while alpha activity undergoes a clear circadian modulation.
Interindividual differences in sleep-wake regulation in young volunteers are associated with the variable-number tandem-repeat (VNTR) polymorphism in the coding region of the circadian clock gene PERIOD3 (PER3). Individuals homozygous for the longer allele of PER3 (PER3 5/5) were reported to generate more slow wave activity during NREM sleep and theta activity during wakefulness, relative to individuals with the shorter allele (PER3 4/4). However, the phase and amplitude of circadian markers do not differ between these genotypes.
Here we tested the hypothesis if fluctuations in the dynamics of waking EEG frequency-specificity are modulated by a polymorphism in the clock gene PER3, under 42h of sustained wakefulness.
|Cyclotron Research Centre, University of Liège, Belgium|
|File(s) associated to this reference|
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