Reference : Ustekinumab in psoriasis immunopathology with emphasis on the Th17-IL23 axis. A primer.
Scientific journals : Article
Human health sciences : Dermatology
http://hdl.handle.net/2268/127851
Ustekinumab in psoriasis immunopathology with emphasis on the Th17-IL23 axis. A primer.
English
QUATRESOOZ, Pascale mailto [Centre Hospitalier Universitaire de Liège - CHU > > Dermatopathologie >]
Hermanns-Le, Trinh mailto [Centre Hospitalier Universitaire de Liège - CHU > > Dermatopathologie >]
Pierard, Gérald mailto [Université de Liège - ULg > Département des sciences cliniques > Département des sciences cliniques >]
Humbert, Philippe [> >]
DELVENNE, Philippe mailto [Centre Hospitalier Universitaire de Liège - CHU > > Anatomie pathologique >]
FRANCHIMONT, Claudine mailto [Centre Hospitalier Universitaire de Liège - CHU > > Dermatopathologie >]
2012
Journal of Biomedicine & Biotechnology
Hindawi Publishing Corporation
2012
147413
Yes (verified by ORBi)
International
1110-7243
1110-7251
United States
[en] Psoriasis is a chronic relapsing immunoinflammatory dermatosis that is commonly associated with systemic comorbidities. The pathogenic importance of interleukin (IL)-12 and IL-23 is beyond doubt, as well as the involvement of T helper cells (Th)1 and Th17 cells. There is upregulation of the p40 subunit shared by IL-12 and IL-23 and of the IL-23 p19 subunit, but not an increased expression of the IL-12 p35 subunit. This indicates that IL-23 appears more involved than IL-12 in the pathogenesis of psoriatic plaques. Ustekinumab is a fully human monoclonal antibody of the immunoglobulin (Ig) G1 class targeting the p40 subunit common to both IL-12 and IL-23, thus inhibiting both IL-12 and IL-23 receptor-mediated signalling. Ustekinumab is part of the recent biologic therapies active in psoriasis, autoimmune arthritides, and inflammatory bowel diseases.
http://hdl.handle.net/2268/127851
also: http://hdl.handle.net/2268/130154
10.1155/2012/147413

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