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Genome-wide association analysis identifies susceptibility loci for migraine without aura.
Freilinger, Tobias; Anttila, Verneri; de Vries, Boukje et al.
2012In Nature Genetics, 44 (7), p. 777-82
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Abstract :
[en] Migraine without aura is the most common form of migraine, characterized by recurrent disabling headache and associated autonomic symptoms. To identify common genetic variants associated with this migraine type, we analyzed genome-wide association data of 2,326 clinic-based German and Dutch individuals with migraine without aura and 4,580 population-matched controls. We selected SNPs from 12 loci with 2 or more SNPs associated with P values of <1 x 10(-5) for replication testing in 2,508 individuals with migraine without aura and 2,652 controls. SNPs at two of these loci showed convincing replication: at 1q22 (in MEF2D; replication P = 4.9 x 10(-4); combined P = 7.06 x 10(-11)) and at 3p24 (near TGFBR2; replication P = 1.0 x 10(-4); combined P = 1.17 x 10(-9)). In addition, SNPs at the PHACTR1 and ASTN2 loci showed suggestive evidence of replication (P = 0.01; combined P = 3.20 x 10(-8) and P = 0.02; combined P = 3.86 x 10(-8), respectively). We also replicated associations at two previously reported migraine loci in or near TRPM8 and LRP1. This study identifies the first susceptibility loci for migraine without aura, thereby expanding our knowledge of this debilitating neurological disorder.
Disciplines :
Neurology
Author, co-author :
Freilinger, Tobias
Anttila, Verneri
de Vries, Boukje
Malik, Rainer
Kallela, Mikko
Terwindt, Gisela M.
Pozo-Rosich, Patricia
Winsvold, Bendik
Nyholt, Dale R.
van Oosterhout, Willebrordus P. J.
Artto, Ville
Todt, Unda
Hamalainen, Eija
Fernandez-Morales, Jessica
Louter, Mark A.
Kaunisto, Mari A.
SCHOENEN, Jean  ;  Centre Hospitalier Universitaire de Liège - CHU > Neurologie CHR
Raitakari, Olli
Lehtimaki, Terho
Vila-Pueyo, Marta
Gobel, Hartmut
Wichmann, Erich
Sintas, Celia
Uitterlinden, Andre G.
Hofman, Albert
Rivadeneira, Fernando
Heinze, Axel
Tronvik, Erling
van Duijn, Cornelia M.
Kaprio, Jaakko
Cormand, Bru
Wessman, Maija
Frants, Rune R.
Meitinger, Thomas
Muller-Myhsok, Bertram
Zwart, John-Anker
Farkkila, Markus
Macaya, Alfons
Ferrari, Michel D.
Kubisch, Christian
Palotie, Aarno
Dichgans, Martin
van den Maagdenberg, Arn M. J. M.
More authors (33 more) Less
Language :
English
Title :
Genome-wide association analysis identifies susceptibility loci for migraine without aura.
Publication date :
2012
Journal title :
Nature Genetics
ISSN :
1061-4036
eISSN :
1546-1718
Publisher :
Nature Publishing Group, United Kingdom
Volume :
44
Issue :
7
Pages :
777-82
Peer reviewed :
Peer Reviewed verified by ORBi
Available on ORBi :
since 05 September 2012

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