Reference : On a fundamental structure of gene networks in living cells

	Document type :	Scientific journals : Article
	Discipline(s) :	Life sciences : Biochemistry, biophysics & molecular biology
	To cite this reference:	http://hdl.handle.net/2268/129965

Title :	On a fundamental structure of gene networks in living cells
Language :	English
Author, co-author :	Kravchenko-Balasha, Nataly [> >]
	Levitzki, Alexander [> >]
	Goldstein, Andrew [> >]
	Rotter, Varda [> >]
	Gross, A. [> >]
	Remacle, Françoise [Université de Liège - ULg > Département de chimie (sciences) > Laboratoire de chimie physique théorique >]
	Levine, R. D. [> >]
Publication date :	2012
Journal title :	Proceedings of the National Academy of Sciences of the United States of America
Volume :	109
Issue/season :	12
Pages :	4702-4707
Audience :	International
ISSN :	1091-6490
Permalink :	http://hdl.handle.net/2268/129965
Other URL :	http://www.pnas.org/content/109/12/4702.abstractN2 - Computers are organized into hardware and software. Using a theoretical approach to identify patterns in gene expression in a variety of species, organs, and cell types, we found that biological systems similarly are comprised of a relatively unchanging hardware-like gene pattern. Orthogonal patterns of software-like transcripts vary greatly, even among tumors of the same type from different individuals. Two distinguishable classes could be identified within the hardware-like component: those transcripts that are highly expressed and stable and an adaptable subset with lower expression that respond to external stimuli. Importantly, we demonstrate that this structure is conserved across organisms. Deletions of transcripts from the highly stable core are predicted to result in cell mortality. The approach provides a conceptual thermodynamic-like framework for the analysis of gene-expression levels and networks and their variations in diseased cells.

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