Article (Scientific journals)
Chemometrics and chromatographic fingerprints to discriminate and classify counterfeit medicines containing PDE-5 inhibitors.
Deconinck, Eric; Sacre, Pierre-Yves; Courselle, Patricia et al.
2012In Talanta, 100, p. 123-133
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Keywords :
Chromatographic fingerprints; PDE-5 inhibitors; Counterfeit medicines; chemometrics
Abstract :
[en] Chromatographic fingerprints recorded for a set of genuine and counterfeit samples of Viagra® and Cialis® were evaluated for their use in the detection and classification of counterfeit samples of these groups of medicines. Therefore several exploratory chemometric techniques were applied to reveal structures in the data sets as well as differences among the samples. The focus was on the differentiation between genuine and counterfeit samples and on the differences between the samples of the different classes of counterfeits as defined by the Dutch National Institute for Public Health and the Environment (RIVM). In a second part the revealed differences between the samples were modelled to obtain a predictive model for both the differentiation between genuine and counterfeit samples as well as the classification of the counterfeit samples. The exploratory analysis clearly revealed differences in the data for the genuine and the counterfeit samples and with projection pursuit and hierarchical clustering differences among the different groups of counterfeits could be revealed, especially for the Viagra® data set. For both data sets predictive models were obtained with 100% correct classification rates for the differentiation between genuine and counterfeit medicines and high correct classification rates for the classification in the different classes of counterfeit medicines. For both data sets the best performing models were obtained with Least Square-Support Vector Machines (LS-SVM) and Soft Independent Modelling by Class Analogy (SIMCA).
Disciplines :
Pharmacy, pharmacology & toxicology
Author, co-author :
Deconinck, Eric
Sacre, Pierre-Yves  ;  Université de Liège - ULiège > Département de pharmacie > Chimie analytique
Courselle, Patricia
De Beer, Jacques
Language :
English
Title :
Chemometrics and chromatographic fingerprints to discriminate and classify counterfeit medicines containing PDE-5 inhibitors.
Publication date :
15 October 2012
Journal title :
Talanta
ISSN :
0039-9140
eISSN :
1873-3573
Publisher :
Elsevier Science, Amsterdam, Netherlands
Volume :
100
Pages :
123-133
Peer reviewed :
Peer Reviewed verified by ORBi
Available on ORBi :
since 03 September 2012

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