Langholz D, Louie EK, Konstadt SN, Rao TL, Scanlon PJ. Transesophageal echocardiographic demonstration of distinct mechanisms for right to left shunting across a patent foramen ovale in the absence of pulmonary hypertension. J Am Coll Cardiol 1991;18:1112-17.
Sukernik MR, Bennett-Guerrero E. The incidental finding of a patent foramen ovale during cardiac surgery: should it always be repaired? A core review. Anesth Analg 2007;105:602-10.
Gillis CN, Pitt BR. The fate of circulating amines within the pulmonary circulation. Ann Rev Physiol 1982;44:269-81.
Jauss M, Zanette E. Detection of right-to-left shunt with ultrasound contrast agent and transcranial Doppler sonography. Cerebrovasc Dis 2000;10: 490-6.
Spencer MP, Moehring MA, Jesurum J, Gray WA, Olsen JV, Reisman M. Power m-mode transcranial Doppler for diagnosis of patent foramen ovale and assessing transcatheter closure. J Neuroimaging 2004;14:342-9.
Shalchian S, Gèrardy PY, Damas F, Schoenen J. Prevalence of patent foramen ovale and MRI white matter lesions in migraine with aura: a cross-sectional study. Cephalalgia 2009;29:120.
Schoenen J, Burette P, Materne P. Patent foramen ovale and migraine: incidental or causal association. Rev Med Liège 2006; 61:9-15.
Hagen PT, Scholz DG, Edwards WD. Incidence and size of patent foramen ovale during the first 10 decades of life: an autopsy study of 965 normal hearts. Mayo Clin Proc 1984;59:17-20.
Penther P. Patent foramen ovale: an anatomical study. A propos of 500 consecutive autopsies. Arch Mal Coeur Vaiss 1994;87:15-21.
Meissner I, Whisnant JP, Khandheria BK, et al. Prevalence of potential risk factors for stroke assessed by transesophageal echocardiography and carotid ultrasonography: the SPARC study. Stroke Prevention: Assessment of Risk in a Community. Mayo Clin Proc 1999;74:862-9.
Anzola GP, Magoni MD, Guindani M, Rozzini L, Dalla Volta GD. Potential source of cerebral embolism in migraine with aura. A transcranial Doppler study. Neurology 1999;52:1622-5.
Domitrz I, Mieszkowski J, Kwiecinski H. The prevalence of patent foramen ovale in patients with migraine. Neurol Neurochir Pol 2004;38: 89-92.
Dalla Volta G, Guindani M, Zavarise P, Griffini S, Pezzini A, Padovani A. Prevalence of patent foramen ovale in a large series of patients with migraine with aura, migraine without aura and cluster headache, and relationship with clinical phenotype. J Headache Pain 2005;6:328-30.
Ferrarini G, Malferrari G, Zucco R, Gaddi O, Norina M, Pini LA. High prevalence of patent foramen ovale in migraine with aura. J Headache Pain 2005;6:71-6.
Carod-Artal FJ, da Silveira Ribeiro L, Braga H, Kummer W, Mesquita HM, Vargas AP. Prevalence of patent foramen ovale in migraine patients with and without aura compared with stroke patients. A transcranial Doppler study. Cephalalgia 2006;26:934-9.
Tembl J, Lago A, Sevilla T, Solis P, Vilchez J. Migraine, patent foramen ovale and migraine triggers. J Headache Pain 2007;8:7-12.
Schwedt TJ, Demaerschalk BM, Dodick DW. Patent foramen ovale and migraine: a quantitative systematic review. Cephalalgia 2008;28:531-40.
Schwedt TJ, Dodick DW. Patent foramen ovale and migraine - bringing closure to the subject. Headache 2006;46:663-71.
Stewart WF, Lipton RB, Celentano DO et. al. Prevalence of migraine headache in the United States: relation to age, income, race, and other socioeconomic factors. JAMA 1992;267:64-9.
Lipton RB, Stewart WF, Diamond S, Diamond ML, Reed M. Prevalence and burden of migraine in the United States: data from the American Migraine Study II. Headache 2001;41:646-57.
Rasmussen BK. Epidemiology of headache. Cephalalgia 2001;21:774-7.
Sztajzel R, Genoud D, Roth S, Mermillod B, Le Floch-Rohr J. Patent foramen ovale, a possible cause of symptomatic migraine: a study of 74 patients with acute ischemic stroke. Cerebrovasc Dis 2002;13:102-6.
Wilmshurst P, Pearson M, Nightingale S. Re-evaluation of the relationship between migraine and persistent foramen ovale and other right-to-left shunts. Clin Sci (Lond) 2005;108:365-7.
Reisman M, Christofferson RD, Jesurum J, et al. Migraine headache relief after transcatheter closure of patent foramen ovale. J Am Coll Cardiol 2005;45:493-5.
Post MC, Thijs V, Herroelen L, Budts WI. Closure of a patent foramen ovale is associated with a decrease in prevalence of migraine. Neurology 2004;62:1439-40.
Schwerzmann M, Wiher S, Nedeltchev K, et al. Percutaneous closure of patent foramen ovale reduces the frequency of migraine attacks. Neurology 2004;62:1399-401.
Morandi E, Anzola GP, Angeli S, Melzi G, Onorato E. Transcatheter closure of patent foramen ovale: a new migraine treatment. J Interv Cardiol 2003;16:39-42.
Wilmshurst P, Nightingale S. Relationship between migraine and cardiac and pulmonary right-to-left shunts. Clin Sci (Lond) 2001;100:215-20.
Anzola GP, Frisoni GB, Morandi E, Casilli F, Onorato E. Shunt-associated migraine responds favorably to atrial septal repair: a case-control study. Stroke 2006;37:430-4.
Anzola GP, Morandi E, Casilli F, Onorato E. Different degrees of right-to-left shunting predict migraine and stroke: data from 420 patients. Neurology 2006;66:765-7.
Wilmshurst P, Nightingale S, Pearson M, Morrison L, Walsh K. Relation of atrial shunts to migraine in patients with ischemic stroke and peripheral emboli. Am J Cardiol 2006;98:831-3.
Kimmelstiel C, Gange C, Thaler D. Is patent foramen ovale closure effective in reducing migraine symptoms? A controlled study. Catheter Cardiovasc Interv 2007;69:740-6.
Schwerzmann M, Nedeltchev K, Lagger F, et al. Prevalence and size of directly detected patent foramen ovale in migraine with aura. Neurology 2005;65:1415-18.
Jesurum JT, Fuller CJ, Velez CA, et al. Migraineurs with patent foramen ovale have larger right-to-left shunt despite similar atrial septal characteristics. J Headache Pain 2007;8:209-16.
James MF, Smith MI, Bockhorst KH et al. Cortical spreading depression in the gyrencephalic feline brain studied by magnetic resonance imaging. J Physiol 1999;519;415-25.
Nozari A, Dilekoz E, Sukhotinsky I et al. Microemboli may link spreading depression, migraine aura, and patent foramen ovale. Ann Neurol 2010;67:221-9.
Wang Z, Li P, Luo W, Chen S, Luo Q. Peri-infarct temporal changes in intrinsic optical signal during spreading depression in focal ischemic rat cortex. Neurosci Lett 2007;424:133-8.
Schwedt TJ. Serotonin and migraine: the latest developments. Cephalalgia 2007;27:1301-7.
Ferrari MD, Odink J, Tapparelli C, Van Kempen GMJ, Pennings EJM, Bruyn GW. Serotonin metabolism in migraine. Neurology 1989;39:1239-42.
Sicuteri F, Testi A, Anselmi B. Biochemical investigations in headache: increase in the hydroxyindoleacetic acid excretion during migraine attacks. Int Arch Allergy 1961;19:55-8.
Sakai Y, Dobson C, Diksic M, Aubè M, Hamel E. Sumatriptan normalizes the migraine attack-related increase in brain serotonin synthesis. Neurology 2008;70;431-9.
Tietjen GE, Herial NA, Utley C, White L, Yerga-Woolwine S, Joe B. Association of von Willebrand factor activity with ACE I/D and MTHFR C677T polymorphisms in migraine. Cephalalgia 2009;29:960-8.
Nahas SJ, Young WB, Terry R et al. Right-to-left shunt is common in chronic migraine. Cephalalgia 2010;30:535-42.
Shalchian S, Ashina M, Guo S, Küper M, Katsarava Z, Schoenen J. Left shunt prevalence on ctcd in chronic migraine with or without medication overuse headache: a cross-sectional study. Acta Neurol Belg 2010;110(Suppl. 1):46.
Wilmshurst PT, Nightingale S, Walsh KP et. al. Effect on migraine of closure of cardiac right-to-left shunts to prevent recurrence of decompression illness or stroke for haemodynamic reasons. Lancet 2000;356:1648-51.
Wilmshurst PT, Nightingale S, Walsh KP, Morrison WL. Clopidogrel reduces migraine with aura after transcatheter closure of persistent foramen ovale and atrial septal defects. Heart 2005;91:1173-5.
Dinia L, Roccatagliata L, Bonzano L, Finocchi C, Del Sette M. Diffusion MRI during migraine with aura attack associated with diagnostic microbubbles injection in subjects with large PFO. Headache 2007;47:1455-6.
Post MC, Thijs V, Schonewille WJ, et al. Embolization of pulmonary arteriovenous malformations and decrease in prevalence of migraine. Neurology 2006;66:202-5.
Truong T, Slavin L, Kashani R et. al. Prevalence of migraine headaches in patients with congenital heart disease. Am J Cardiol 2008;101:396-400.
Gori S, Morelli N, Fannucchi S, et al. The extent of right-to-left shunt fails to correlate with severity of clinical picture in migraine with aura. Neurol Sci 2006;27:14-17.
Wilmshurst PT, Pearson MJ, Nightingale S, Walsh KP, Morrison WL. Inheritance of persistent foramen ovale and atrial septal defects and the relation to familial migraine with aura. Heart 2004;90:1315-20.
Anzola GP, Meneghetti G, Zanferrari C, Adami A, Dinia L, Del Sette M, for the SAM Study Group. Is migraine associated with right-to-left shunt a separate disease? Results of the SAM study. Cephalalgia 2008;28:360-6.
Del Sette M, Angeli S, Leandri M et. al. Migraine with aura and right-to-left shunt on transcranial Doppler: a case-control study. Cerebrovasc Dis 1998;8:327-30.
Azarbal B, Tobis J, Suh W et. al. Association of interatrial shunts and migraine headaches. J Am Coll Cardiol 2005;45:489-92.
Giardini A, Donti A, Formigari R, et al. Transcatheter patent foramen ovale closure mitigates aura migraine headaches abolishing spontaneous right-toleft shunting. Am Heart J 2006;151:922.e1-5.
Jesurum JT, Fuller CJ, Kim CJ, et al. Frequency of migraine headache relief following patent foramen ovale 'closure' despite residual right-to-left shunt. Am J Cardiol 2008;102:916-20.
Dowson A, Mullen MJ, Peatfield R, et al. Migraine Intervention With STARFlex Technology (MIST) Trial: A prospective, multicenter, double-blind, sham-controlled trial to evaluate the effectiveness of patent foramen ovale closure with STARFlex septal repair implant to resolve refractory migraine headache. Circulation 2008;117:1397-404.
Marchione P, Ghiotto N, Sances G, et al. Clinical implications of patent foramen ovale in migraine with aura. Funct Neurol 2008;23:201-5.
Kruit MC, van Buchem MA, Hofman PAM, et al. Migraine as a risk factor for subclinical brain lesions. JAMA 2004;291:427-34.
Kruit MC, Launer LJ, Ferrari M, van Buchem MA. Infarcts in the posterior circulation territory in migraine. The population-based MRI CAMERA study. Brain 2005;128:2068-77.
Del Sette M, Dinia L, Bonzano L, et al. White matter lesions in migraine and right-to-left shunt: a conventional and diffusion MRI study. Cephalalgia 2008;28:376-82.
Adami A, Rossato G, Cerini R, et al. on behalf of the SAM Study Group. Right-to-left shunt does not increase white matter lesion load in migraine with aura patients. Neurology 2008;71:101-7.
Ramírez-Moreno JM, Casado-Naranjo I, Gómez M, et al. Migraine with aura and patent foramen ovale. A different clinical entity? Neurologia 2008;23:503-10.
