ORBi: Bicchielli Dario - Olefin metathesis as key step in the synthesis of bioactive compounds: Challenges in the total synthesis of (-)-kendomycin

Reference : Olefin metathesis as key step in the synthesis of bioactive compounds: Challenges in the...


	Document type :	Scientific journals : Article
	Discipline(s) :	Physical, chemical, mathematical & earth Sciences : Chemistry
	To cite this reference:	http://hdl.handle.net/2268/129703

Title :	Olefin metathesis as key step in the synthesis of bioactive compounds: Challenges in the total synthesis of (-)-kendomycin
Language :	English
Author, co-author :	Bicchielli, Dario [Laboratory of Macromolecular Chemistry and Organic Catalysis, University of Liège, Sart-Tilman (B.6a), B-4000 Liège, Belgium]
	Borguet, Yannick [Université de Liège - ULg > Département de chimie (sciences) > Chimie macromoléculaire et catalyse organique >]
	Delaude, Lionel [Université de Liège - ULg > Département de chimie (sciences) > Chimie organométallique et catalyse homogène >]
	Demonceau, Albert [Université de Liège - ULg > Département de chimie (sciences) > Chimie macromoléculaire et catalyse organique >]
	Dragutan, Ileana [Institute of Organic Chemistry of the Romanian Academy, 202B Spl. Independentei, P.O. Box 35-108, 060023 Bucharest, Romania]
	Dragutan, Valerian [Institute of Organic Chemistry of the Romanian Academy, 202B Spl. Independentei, P.O. Box 35-108, 060023 Bucharest, Romania]
	Hans, Morgan [Université de Liège - ULg > Département de chimie (sciences) > Chimie macromoléculaire et catalyse organique >]
	Jossifov, Christo [Institute of Polymers, Bulgarian Academy of Sciences, Acad. Georgy Bonchev Str., bl. 103-A, 1113 Sofia, Bulgaria]
	Nicks, Francois [Université de Liège - ULg > Chimie et bio-industries > Chimie biologique industrielle >]
	Willem, Quentin [Laboratory of Macromolecular Chemistry and Organic Catalysis, University of Liège, Sart-Tilman (B.6a), B-4000 Liège, Belgium]
Publication date :	2012
Journal title :	Current Organic Synthesis
Publisher :	Bentham Science Publ Ltd
Volume :	9
Issue/season :	3
Pages :	397-405
Audience :	International
ISSN :	1570-1794
City :	Sharjah
Country :	India
Keywords :	[en] Homogeneous catalysis ; Kendomycin ; Macrocyclisation ; Olefin metathesis ; Polyketide ; Ruthenium catalysts
Abstract :	[en] In this short review article, we highlight the application of the olefin metathesis reaction as a key step in the total synthesis of (-)-kendomycin, a macrocyclic polyketide ansamycin exhibiting pronounced activity as an endothelin receptor antagonist and antiosteoporotic agent, as well as important antibiotic potency against multiresistant bacteria and remarkable cytotoxicity versus a series of human tumour cell lines. By selecting this example from the recent literature, we hope to illustrate the great synthetic ability of olefin metathesis, while also revealing some problems encountered in the syntheses. © 2012 Bentham Science Publishers.
Target :	Researchers ; Professionals
Permalink :	http://hdl.handle.net/2268/129703
DOI :	10.2174/157017912801270586

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