Reference : Olefin metathesis as key step in the synthesis of bioactive compounds: Challenges in the...
Scientific journals : Article
Physical, chemical, mathematical & earth Sciences : Chemistry
http://hdl.handle.net/2268/129703
Olefin metathesis as key step in the synthesis of bioactive compounds: Challenges in the total synthesis of (-)-kendomycin
English
Bicchielli, Dario [Laboratory of Macromolecular Chemistry and Organic Catalysis, University of Liège, Sart-Tilman (B.6a), B-4000 Liège, Belgium]
Borguet, Yannick mailto [Université de Liège - ULg > Département de chimie (sciences) > Chimie macromoléculaire et catalyse organique >]
Delaude, Lionel mailto [Université de Liège - ULg > Département de chimie (sciences) > Chimie organométallique et catalyse homogène >]
Demonceau, Albert mailto [Université de Liège - ULg > Département de chimie (sciences) > Chimie macromoléculaire et catalyse organique >]
Dragutan, Ileana [Institute of Organic Chemistry of the Romanian Academy, 202B Spl. Independentei, P.O. Box 35-108, 060023 Bucharest, Romania]
Dragutan, Valerian [Institute of Organic Chemistry of the Romanian Academy, 202B Spl. Independentei, P.O. Box 35-108, 060023 Bucharest, Romania]
Hans, Morgan mailto [Université de Liège - ULg > Département de chimie (sciences) > Chimie macromoléculaire et catalyse organique >]
Jossifov, Christo [Institute of Polymers, Bulgarian Academy of Sciences, Acad. Georgy Bonchev Str., bl. 103-A, 1113 Sofia, Bulgaria]
Nicks, Francois [Université de Liège - ULg > Chimie et bio-industries > Chimie biologique industrielle >]
Willem, Quentin [Laboratory of Macromolecular Chemistry and Organic Catalysis, University of Liège, Sart-Tilman (B.6a), B-4000 Liège, Belgium]
2012
Current Organic Synthesis
Bentham Science Publ Ltd
9
3
397-405
Yes (verified by ORBi)
International
1570-1794
Sharjah
United Arab Emirates
[en] Homogeneous catalysis ; Kendomycin ; Macrocyclisation ; Olefin metathesis ; Polyketide ; Ruthenium catalysts
[en] In this short review article, we highlight the application of the olefin metathesis reaction as a key step in the total synthesis of (-)-kendomycin, a macrocyclic polyketide ansamycin exhibiting pronounced activity as an endothelin receptor antagonist and antiosteoporotic agent, as well as important antibiotic potency against multiresistant bacteria and remarkable cytotoxicity versus a series of human tumour cell lines. By selecting this example from the recent literature, we hope to illustrate the great synthetic ability of olefin metathesis, while also revealing some problems encountered in the syntheses. © 2012 Bentham Science Publishers.
Researchers ; Professionals
http://hdl.handle.net/2268/129703
10.2174/157017912801270586

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