ORBi: Cerda-Cristerna Bernardino Issac - Poly(2-dimethylamino ethylmethacrylate)-based polymers to camouflage red blood cell antigens.

Reference : Poly(2-dimethylamino ethylmethacrylate)-based polymers to camouflage red blood cell anti...


	Document type :	Scientific journals : Article
	Discipline(s) :	Human health sciences : Pharmacy, pharmacology & toxicology Human health sciences : Immunology & infectious disease
	To cite this reference:	http://hdl.handle.net/2268/129626

Title :	Poly(2-dimethylamino ethylmethacrylate)-based polymers to camouflage red blood cell antigens.
Language :	English
Author, co-author :	Cerda-Cristerna, Bernardino Issac []
	Cottin, Sophie [> >]
	Flebus, Luca [> >]
	Pozos-Guillen, Amaury [> >]
	Flores, Hector [> >]
	Heinen, Ernst [Université de Liège - ULg > Département des sciences biomédicales et précliniques > Histologie humaine >]
	Jolois, Olivier [Université de Liège - ULg > Département des sciences biomédicales et précliniques > Histologie humaine >]
	GERARD, Christiane [Centre Hospitalier Universitaire de Liège - CHU > > Hématologie biologique et immuno hématologie >]
	MAGGIPINTO, Gianni [Centre Hospitalier Universitaire de Liège - CHU > > Hématologie biologique et immuno hématologie >]
	Sevrin, Chantal [> >]
	Grandfils, Christian [Université de Liège - ULg > Département des sciences biomédicales et précliniques > Biochimie et physiologie générales, et biochimie humaine >]
Publication date :	2012
Journal title :	Biomacromolecules
Volume :	13
Issue/season :	4
Pages :	1172-80
ISSN :	1525-7797
e-ISSN :	1526-4602
Country :	United States
Abstract :	[en] Poly(2-dimethylamino-ethylmethacrylate) (PDMAEMA) is a cationic polymer when dissolved in a 7.4 pH fluid. Owing to its ionic nature, this polycation interacts with the negatively charged cell membrane surface of red blood cells (RBCs). The electrostatic self-assembly of PDMAEMA on RBCs membrane can be employed for inducing the formation of a polymeric shield camouflaging blood group antigens on RBCs as a valuable strategy for developing "universal RBCs" for blood transfusion. The purpose of this research was to evaluate the camouflaging ability of PDMAEMA homopolymers and PDMAEMA-co-poly(ethylene glycol) copolymers differing in molecular weight and architecture. Surprisingly, the PDMAEMAs caused a partially masking, no masking, and sensitization of the same RBCs population. The MW and architecture of the polymers as well as temperature of PDMAEMA-RBCs treatment influenced the results observed. Herein, the very particular reactivity of PDMAEMAs and RBCs is analyzed and discussed.
Permalink :	http://hdl.handle.net/2268/129626
DOI :	10.1021/bm300127f

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