Reference : Poly(2-dimethylamino ethylmethacrylate)-Based Polymers To Camouflage Red Blood Cell Anti...
Scientific journals : Article
Human health sciences : Pharmacy, pharmacology & toxicology
Human health sciences : Immunology & infectious disease
Life sciences : Biochemistry, biophysics & molecular biology
http://hdl.handle.net/2268/129626
Poly(2-dimethylamino ethylmethacrylate)-Based Polymers To Camouflage Red Blood Cell Antigens
English
Cerda Cristerna, Bernardino Isaac mailto [Université de Liège - ULg > > > GIGA - Utilisateurs machines]
COTTIN, Sophie [Centre Hospitalier Universitaire de Liège - CHU > > Hématologie biologique et immuno hématologie >]
Flebus, Luca mailto [Université de Liège - ULg > > Centre interfacultaire des biomatériaux (CEIB) >]
Pozos-Guillén, Amaury [> >]
Flores, Héctor [> >]
Heinen, Ernst mailto [Université de Liège - ULg > Département des sciences biomédicales et précliniques > Histologie humaine >]
Jolois, Olivier mailto [Université de Liège - ULg > Département des sciences biomédicales et précliniques > Histologie humaine >]
GERARD, Christiane mailto [Centre Hospitalier Universitaire de Liège - CHU > > Hématologie biologique et immuno hématologie >]
MAGGIPINTO, Gianni mailto [Centre Hospitalier Universitaire de Liège - CHU > > Hématologie biologique et immuno hématologie >]
Sevrin, Chantal mailto [Université de Liège - ULg > > Centre interfacultaire des biomatériaux (CEIB) >]
Grandfils, Christian mailto [Université de Liège - ULg > Département des sciences biomédicales et précliniques > Biochimie et physiologie générales, et biochimie humaine >]
2012
Biomacromolecules
American Chemical Society
13
4
1172-1180
Yes
International
1525-7797
1526-4602
Washington
DC
[en] Poly (2-dimethylamino-ethylmethacrylate) ; red blood cells ; polycation ; stealth red blood cells ; immunocamouflage ; cell surface engineering ; universal red blood cells
[en] Poly(2-dimethylamino-ethylmethacrylate) (PDMAEMA) is a cationic polymer when dissolved in a 7.4 pH fluid. Owing to its ionic nature, this polycation interacts with the negatively charged cell membrane surface of red blood cells (RBCs). The electrostatic self-assembly of PDMAEMA on RBCs membrane can be employed for inducing the formation of a polymeric shield camouflaging blood group antigens on RBCs as a valuable strategy for developing “universal RBCs” for blood transfusion. The purpose of this research was to evaluate the camouflaging ability of PDMAEMA homopolymers and PDMAEMA-copoly(nethylene glycol) copolymers differing in molecular weight and architecture. Surprisingly, the PDMAEMAs caused a partially masking, no masking, and sensitization of the same RBCs population. The MW and architecture of the polymers as well as temperature of PDMAEMA-RBCs treatment influenced the results observed. Herein, the very particular reactivity of PDMAEMAs and RBCs is analyzed and discussed.
Centre Interfacultaire des Biomatériaux - CEIB
EU FP6 IP NanoBioPharmaceutics ; Doctorado Institucional en Ingeniería y Ciencia de Materiales-CONACYT México
Researchers ; Professionals ; Students
http://hdl.handle.net/2268/129626
also: http://hdl.handle.net/2268/137637
10.1021/bm300127f
http://pubs.acs.org/doi/abs/10.1021/bm300127f

File(s) associated to this reference

Fulltext file(s):

FileCommentaryVersionSizeAccess
Open access
Cerda 2012.pdfPublisher postprint447.46 kBView/Open

Bookmark and Share SFX Query

All documents in ORBi are protected by a user license.