Reference : Inositol 1,4,5-trisphosphate 3-kinase B (Itpkb) controls survival, proliferation and cyt...
Scientific journals : Article
Life sciences : Biochemistry, biophysics & molecular biology
http://hdl.handle.net/2268/129594
Inositol 1,4,5-trisphosphate 3-kinase B (Itpkb) controls survival, proliferation and cytokine production in mouse peripheral T cells
English
Pouillon, Valérie [Institut de Recherches Interdisciplinaires en Biologie Humaine et Moléculaire (IRIBHM), Belgium > > > >]
Maréchal, Yoann [Université Libre de Bruxelles - ULB > Institut de Biologie et de Médecine Moléculaires (IBMM), Faculté de Médecine > > >]
Frippiat, Christophe [Université Libre de Bruxelles - ULB > Institut de Biologie et de Médecine Moléculaires (IBMM), Faculté de Médecine > > >]
Erneux, Christophe [Institut de Recherches Interdisciplinaires en Biologie Humaine et Moléculaire (IRIBHM), Belgium > > > >]
Schurmans, Stéphane mailto [Université de Liège - ULg > Département de sciences fonctionnelles > Biochimie métabolique vétérinaire >]
2013
Advances in Biological Regulation
Elsevier
53
1
39-50
Yes
International
2212-4926
[en] T lymphocyte ; inositol phosphate ; kinase
[en] Mice genetically-deficient for the B isoform of the inositol 1,4,5-trisphosphate 3-kinase (or Itpkb) have a severe defect in thymocytes differentiation and thus lack peripheral T cells. In order to study the functional role of Itpkb in peripheral T cells, we constructed a new mouse where a transgene encoding mouse Itpkb is specifically and transiently expressed in thymocytes of Itpkb-/- mice. This allows a partial rescue of mature thymocyte/T cell differentiation and thus the functional characterization of peripheral T cells lacking Itpkb. We show here that Itpkb-/- CD4+ and CD8+ peripheral T cells present important functional alterations. Indeed, an increased activated/memory phenotype as well as a decreased proliferative capacity and survival were detected in these T cells. These Itpkb-deficient peripheral T cells have also an increased capacity to secrete cytokines upon stimulation. Together, our present results define the important role of Itpkb in peripheral mature T cell fate and function in mouse, suggesting a potential role for Itpkb in autoimmunity.
Researchers ; Professionals
http://hdl.handle.net/2268/129594
10.1016/j.jbior.2012.08.001
http://dx.doi.org/10.1016/j.jbior.2012.08.001

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