ORBi: DETRY Olivier - Effects of Large-Pore Hemofiltration in a Swine Model of Fulminant Hepatic Failure.

Reference : Effects of Large-Pore Hemofiltration in a Swine Model of Fulminant Hepatic Failure.


	Document type :	Scientific journals : Article
	Discipline(s) :	Human health sciences : Surgery Human health sciences : Gastroenterology & hepatology Human health sciences : Urology & nephrology
	To cite this reference:	http://hdl.handle.net/2268/129219

Title :	Effects of Large-Pore Hemofiltration in a Swine Model of Fulminant Hepatic Failure.
Language :	English
Author, co-author :	DETRY, Olivier [Centre Hospitalier Universitaire de Liège - CHU > > Chirurgie abdominale- endocrinienne et de transplantation >]
	JANSSEN, Nathalie [Centre Hospitalier Universitaire de Liège - CHU > > Urgences >]
	CHERAMY-BIEN, Jean-Paul [Centre Hospitalier Universitaire de Liège - CHU > > Chirurgie cardio-vasculaire >]
	Cavalier, Etienne [Université de Liège - ULg > Département de pharmacie > Chimie médicale >]
	Defraigne, Jean-Olivier [Université de Liège - ULg > Département des sciences cliniques > Chirurgie cardio-vasculaire et thoracique >]
	DELANAYE, Pierre [Centre Hospitalier Universitaire de Liège - CHU > > Néphrologie >]
	LAMBERMONT, Bernard [Centre Hospitalier Universitaire de Liège - CHU > > Frais communs médecine >]
Publication date :	Nov-2012
Journal title :	Artificial Organs
Volume :	36
Issue/season :	11
Pages :	981-987
Audience :	International
ISSN :	0160-564X
e-ISSN :	1525-1594
Abstract :	[en] Among the different potential mechanisms that could lead to brain edema and intracranial hypertension in fulminant hepatic failure (FHF), the inflammatory hypothesis implies that systemic inflammation might be in part responsible for an increase in cerebral blood flow (CBF) and brain water content. In this study, the authors used a validated ischemic FHF swine model to evaluate the effects of 80 kDa large-pore membrane hemofiltration (LPHF) on intracranial pressure (ICP) and CBF, in relation with the clearance of proinflammatory cytokines and blood liver tests, as primary end points. Fifteen pigs were randomized into one of three groups: SHAM, FHF, and FHF + LPHF. All experiments lasted 6 h. In the FHF groups, liver failure was induced by liver ischemia. After 2 h, the FHF + LPHF group underwent 4 h of a zero-balance continuous veno-venous hemofiltration using a 0.7-m(2) , large-pore (78 A) membrane with a cutoff of 80 kDa. ICP, CBF, mean arterial pressure, central venous pressure, and heart rate were continuously monitored and recorded. Arterial aspartate aminotransferase, total bilirubin, creatinine, international normalized ratio, glucose, lactate and serum cytokines interleukin (IL)-6, IL-10, and tumor necrosis factor-alpha were measured at T0, T120, and T360. Over the 6 h following liver ischemia, the FHF group developed a significant increase in ICP. This ICP rise was not observed in the SHAM group and was attenuated in the FHF + LDHF group. However, the ICP levels were not different at T360 in the FHF + LDHF group compared to the FHF group. No significant effect of LPHF on liver tests or levels of proinflammatory cytokines could be demonstrated. In this model, 80 kDa LPHF was not efficient to control FHF intracranial hypertension and to decrease serum cytokine levels.
Permalink :	http://hdl.handle.net/2268/129219
DOI :	10.1111/j.1525-1594.2012.01506.x
Commentary :	(c) 2012, Copyright the Authors. Artificial Organs (c) 2012, International Center for Artificial Organs and Transplantation and Wiley Periodicals, Inc.

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