Adult; Blood Glucose/metabolism; Body Temperature; Circadian Rhythm; Exercise/physiology; Hormones/blood; Human Growth Hormone/blood; Humans; Hydrocortisone/blood; Insulin/blood/secretion; Kinetics; Male; Thyrotropin/blood
Abstract :
[en] To study the effects of time of day on neuroendocrine and metabolic responses to exercise, body temperature, plasma glucose, insulin secretion rates (ISR), and plasma cortisol, growth hormone (GH) and thyrotropin (TSH) were measured in young men, both at bed rest and during a 3-h exercise period (40-60% maximal O2 uptake). Exercise was performed at three times of day characterized by marked differences in cortisol levels, i.e., early morning (n = 5), afternoon (n = 8), and around midnight (n = 9). The subjects were kept awake and fasted, but they received a constant glucose infusion to avoid hypoglycemia. Exercise-induced elevations of temperature were higher in the early morning than at other times of day. The exercise-induced glucose decrease was approximately 50% greater around midnight, when cortisol was minimal and not stimulated by exercise, than in the afternoon or early morning (P < 0.05). This effect of time of day appeared unrelated to decreases in ISR or increases in temperature and GH. Robust TSH increases occurred in all exercise periods and were maximal at night. The results demonstrate the existence of circadian variations in neuroendocrine and metabolic responses to exercise.
Disciplines :
Endocrinology, metabolism & nutrition
Author, co-author :
Scheen, André ; Université de Liège - ULiège > Département des sciences cliniques > Diabétologie, nutrition et maladie métaboliques - Médecine interne générale
Buxton, O. M.
Jison, M.
Van Reeth, O.
Leproult, R.
L'Hermite-Baleriaux, M.
Van Cauter, E.
Language :
English
Title :
Effects of exercise on neuroendocrine secretions and glucose regulation at different times of day.
Publication date :
1998
Journal title :
American Journal of Physiology
ISSN :
0002-9513
Publisher :
American Physiological Society, Bethesda, United States - Maryland
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