Reference : Normal reference values for glomerular filtration rate: what do we really know?
Scientific journals : Article
Human health sciences : Laboratory medicine & medical technology
Human health sciences : Urology & nephrology
http://hdl.handle.net/2268/128597
Normal reference values for glomerular filtration rate: what do we really know?
English
DELANAYE, Pierre mailto [Centre Hospitalier Universitaire de Liège - CHU > > Néphrologie >]
Schaeffner, E []
Ebert, N []
CAVALIER, Etienne mailto [Centre Hospitalier Universitaire de Liège - CHU > > Chimie médicale >]
Mariat, C []
KRZESINSKI, Jean-Marie mailto [Centre Hospitalier Universitaire de Liège - CHU > > Néphrologie >]
Moranne, O []
Jul-2012
Nephrology Dialysis Transplantation
Oxford University Press
27
7
2664-72
Yes (verified by ORBi)
International
0931-0509
1460-2385
Oxford
United Kingdom
[en] glomerular filtration rate ; reference values
[en] In nephrology, chronic kidney disease is defined by both proteinuria and measurement of glomerular filtration rate (GFR). This article focuses on GFR and different ways to define its normal reference values. In this context, we compare two perspectives: first the reference values defined by measuring GFR in normal individuals (the 'classical way') and secondly a fixed cut-off value at 60 mL/min/1.73 m(2) according to the associated mortality risk (the 'prognostic way'). Following the classical way, we can assert that normal GFR values are largely over 60 mL/min/1.73 m(2) in healthy subjects, at least before the age of 70 years. However, we know that GFR physiologically decreases with age, and in adults older than 70 years, values below 60 mL/min/1.73 m(2) could be considered normal. Following the 'prognostic way', the fixed cut-off of 60 mL/min/1.73 m(2) has been retained in the K-DIGO guidelines. However, we challenge this concept and the fact that the variable 'age' is poorly taken into account in these data. There is an obvious discrepancy between the reference values defined either by the 'classical way' or by the 'prognostic way' which we think could be largely reduced, if age was better taken into consideration in these definitions.
http://hdl.handle.net/2268/128597

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