ORBi: Mosdzianowski C. - Epimerization study on [18F]FDG produced by an alkaline hydrolysis on solid support under stringent conditions

Reference : Epimerization study on [18F]FDG produced by an alkaline hydrolysis on solid support unde...


	Document type :	Scientific journals : Article
	Discipline(s) :	Human health sciences : Radiology, nuclear medicine & imaging Engineering, computing & technology : Energy Physical, chemical, mathematical & earth Sciences : Chemistry
	To cite this reference:	http://hdl.handle.net/2268/128472

Title :	Epimerization study on [18F]FDG produced by an alkaline hydrolysis on solid support under stringent conditions
Language :	English
Author, co-author :	Mosdzianowski, C. [> > > >]
	Lemaire, Christian [Université de Liège - ULg > > Centre de recherches du cyclotron >]
	Simoens, F. [> > > >]
	Aerts, Joël [Université de Liège - ULg > > Centre de recherches du cyclotron >]
	Morelle, J. L. [> > > >]
	Luxen, André [Université de Liège - ULg > Département de chimie (sciences) > Chimie organique de synthèse - Centre de recherches du cyclotron >]
Publication date :	Jun-2002
Journal title :	Applied Radiation & Isotopes
Publisher :	Pergamon-Elsevier Science Ltd
Volume :	56
Issue/season :	6
Pages :	871-875
Peer reviewed :	Yes (verified by ORBi)
Audience :	International
ISSN :	0969-8043
City :	Oxford
Keywords :	[en] Fluoride ; [F-18]FDG ; [F-18]FDM ; Alkaline ; Hydrolysis ; Solid phase extraction ; Epimerization
Abstract :	[en] Since 1998, routine [18F]FDG syntheses are being carried out by alkaline hydrolysis on a solid support, i.e. the labeled intermediate is trapped on a tC18 solid phase extraction cartridge, purified and finally hydrolyzed within the cartridge, at room temperature, using sodium hydroxide. The present study demonstrated that no epimerization of [18F]FDG to [18F]FDM occurs even when 12 N NaOH is used and when the hydrolysis time is extended up to 1 h. The alkaline hydrolysis on solid support appears to be a simple method leading to [18F]FDG with high purity.
Permalink :	http://hdl.handle.net/2268/128472
DOI :	10.1016/S0969-8043(01)00145-2
Other URL :	http://www.elsevier.com/wps/find/journaldescription.cws_home/228/description#description

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