Reference : Dimebon enhances hippocampus-dependent learning in both appetitive and inhibitory mem...
Scientific journals : Article
Social & behavioral sciences, psychology : Neurosciences & behavior
http://hdl.handle.net/2268/128431
Dimebon enhances hippocampus-dependent learning in both appetitive and inhibitory memory tasks in mice.
English
Vignisse, Julie [Université de Liège - ULg > Département des sciences biomédicales et précliniques > Biochimie et physiologie humaine et pathologique >]
Steinbusch, Harry W. M. [> >]
Bolkunov, Alexei [> >]
Nunes, Joao [> >]
Santos, Ana Isabel [> >]
Grandfils, Christian mailto [Université de Liège - ULg > Département des sciences biomédicales et précliniques > Biochimie et physiologie générales, et biochimie humaine >]
Bachurin, Sergei [> >]
Strekalova, Tatyana [> >]
2011
Progress in Neuro-Psychopharmacology & Biological Psychiatry
Elsevier Science
35
2
The Neurobiology of Neurodegenerative Disorder: From Basic to Clinical Research
510-22
Yes (verified by ORBi)
International
0278-5846
Oxford
United Kingdom
[en] Animals ; Anxiety ; Appetitive Behavior/drug effects ; Avoidance Learning/drug effects ; Drinking/drug effects ; Exploratory Behavior/drug effects ; Hippocampus/drug effects ; Indoles/pharmacology ; Learning/drug effects ; Male ; Maze Learning/drug effects ; Memory/drug effects ; Mice ; Mice, Inbred C57BL ; Nootropic Agents/pharmacology ; Time Factors
[en] Pre-clinical and clinical studies on dimebon (dimebolin or latrepirdine) have demonstrated its use as a cognitive enhancer. Here, we show that dimebon administered to 3-month-old C57BL6N mice 15 min prior to training in both appetitive and inhibitory learning tasks via repeated (0.1 mg/kg) and acute (0.5 mg/kg) i.p. injections, respectively, increases memory scores. Acute treatment with dimebon was found to enhance inhibitory learning, as also shown in the step-down avoidance paradigm in 7-month-old mice. Bolus administration of dimebon did not affect the animals' locomotion, exploration or anxiety-like behaviour, with the exception of exploratory behaviour in older mice in the novel cage test. In a model of appetitive learning, a spatial version of the Y-maze, dimebon increased the rate of correct choices and decreased the latency of accessing a water reward after water deprivation, and increased the duration of drinking behaviour during training/testing procedures. Repeated treatment with dimebon did not alter the behaviours in other tests or water consumption. Acute treatment of water-deprived and non-water-deprived mice with dimebon also did not affect their water intake. Our data suggest that dimebon enhances hippocampus-dependent learning in both appetitive and inhibitory tasks in mice.
http://hdl.handle.net/2268/128431
also: http://hdl.handle.net/2268/128419
Copyright (c) 2011 Elsevier B.V. All rights reserved.

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