Reference : Regulation of HER-2 oncogene expression by cyclooxygenase-2 and prostaglandin E2
Scientific journals : Article
Life sciences : Biochemistry, biophysics & molecular biology
Human health sciences : Oncology
http://hdl.handle.net/2268/1283
Regulation of HER-2 oncogene expression by cyclooxygenase-2 and prostaglandin E2
English
Benoit, Valérie [> > > >]
Relic, Biserka [Centre Hospitalier Universitaire de Liège - CHU > > Rhumatologie >]
de Leval, Laurence mailto [> > > >]
Chariot, Alain mailto [Université de Liège - ULg > Département de pharmacie > Chimie médicale >]
Merville, Marie-Paule mailto [Université de Liège - ULg > Département de pharmacie > Chimie médicale >]
Bours, Vincent mailto [Université de Liège - ULg > Département des sciences biomédicales et précliniques > Génétique générale et humaine]
Feb-2004
Oncogene
Nature Publishing Group
23
8
1631-1635
Yes (verified by ORBi)
International
0950-9232
London
[en] cyclooxygenase-2 ; HER-2 ; erbB-2 ; prostaglandin ; PGE2 ; cancer
[en] The oncoprotein HER-2/neu is a prosurvival factor and its overexpression has been correlated with adverse prognosis in breast cancers. High levels of the cyclooxygenase-2 (COX-2), a proinflammatory and antiapoptotic enzyme, were detected in HER-2-positive tumors and this observation was linked to an HER-2-mediated induction of COX-2 gene transcription. Here, we report that COX-2 expression, and synthesis of its major enzymatic product, PGE2, leads in turn to an enhanced HER-2 expression. Moreover, COX-2 enzymatic inhibition dramatically reduced HER-2 protein levels, efficiently increased the cancer cells sensitility to chemotherapeutic treatment and acted in synergy with HER-2 inhibitor, trastuzumab. Therefore, we propose an original model where HER-2 and COX-2 transcriptionally regulate each other in a positive loop.
Giga-Signal Transduction
FNRS, TELEVIE? FBC, ARC ULG
Researchers ; Professionals ; Students
http://hdl.handle.net/2268/1283
10.1038/sj.onc.1207295

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