Reference : Liver transplantation for unresectable hepatocellular carcinoma in normal livers.
Scientific journals : Article
Human health sciences : Gastroenterology & hepatology
Human health sciences : Surgery
http://hdl.handle.net/2268/128097
Liver transplantation for unresectable hepatocellular carcinoma in normal livers.
English
Mergental, Hynek [> >]
Adam, Rene [> >]
Ericzon, Bo-Goran [> >]
Kalicinski, Piotr [> >]
Muhlbacher, Ferninand [> >]
Hockerstedt, Krister [> >]
Klempnauer, Jurgen L. [> >]
Friman, Styrbjorn [> >]
Broelsch, Christoph E. [> >]
Mantion, Georges [> >]
Fernandez-Sellez, Carlos [> >]
van Hoek, Bart [> >]
Fangmann, Josef [> >]
Pirenne, Jacques [> >]
Muiesan, Paolo [> >]
Konigsrainer, Alfred [> >]
Mirza, Darius F. [> >]
Lerut, Jan [> >]
DETRY, Olivier mailto [Centre Hospitalier Universitaire de Liège - CHU > > Chirurgie abdominale- endocrinienne et de transplantation >]
Le Treut, Yves-Ptrice [> >]
Mazzaferro, Vincenzo [> >]
Lohe, Florian [> >]
Berenguer, Marina [> >]
Clavien, Pierre-Alain [> >]
Rogiers, Xavier [> >]
Belghiti, Jacques [> >]
Kobori, Laslo [> >]
Burra, Patrizia [> >]
Wolf, Philippe [> >]
Schareck, Wolfgang [> >]
Pisarski, Przemyslaw [> >]
Foss, Aksel [> >]
Filipponi, Franco [> >]
Krawczyk, Marek [> >]
Wolff, Martin [> >]
Langrehr, Jan M. [> >]
Rolles, Keith [> >]
Jamieson, Neville [> >]
Hop, Wim C. J. [> >]
Porte, Robert J. [> >]
Aug-2012
Journal of Hepatology
57
2
297-305
Yes (verified by ORBi)
International
0168-8278
England
[en] BACKGROUND & AIMS: The role of liver transplantation in the treatment of hepatocellular carcinoma in livers without fibrosis/cirrhosis (NC-HCC) is unclear. We aimed to determine selection criteria for liver transplantation in patients with NC-HCC. METHODS: Using the European Liver Transplant Registry, we identified 105 patients who underwent liver transplantation for unresectable NC-HCC. Detailed information about patient, tumor characteristics, and survival was obtained from the transplant centers. Variables associated with survival were identified using univariate and multivariate statistical analyses. RESULTS: Liver transplantation was primary treatment in 62 patients and rescue therapy for intrahepatic recurrences after liver resection in 43. Median number of tumors was 3 (range 1-7) and median tumor size 8cm (range 0.5-30). One- and 5-year overall and tumor-free survival rates were 84% and 49% and 76% and 43%, respectively. Macrovascular invasion (HR 2.55, 95% CI 1.34 to 4.86), lymph node involvement (HR 2.60, 95% CI 1.28 to 5.28), and time interval between liver resection and transplantation <12months (HR 2.12, 95% CI 0.96 to 4.67) were independently associated with survival. Five-year survival in patients without macrovascular invasion or lymph node involvement was 59% (95% CI 47-70%). Tumor size was not associated with survival. CONCLUSIONS: This is the largest reported series of patients transplanted for NC-HCC. Selection of patients without macrovascular invasion or lymph node involvement, or patients 12months after previous liver resection, can result in 5-year survival rates of 59%. In contrast to HCC in cirrhosis, tumor size is not a predictor of post-transplant survival in NC-HCC.
http://hdl.handle.net/2268/128097
Copyright (c) 2012 European Association for the Study of the Liver. Published by Elsevier B.V. All rights reserved.

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