Reference : Effects of light deprivation on visual evoked potentials in migraine without aura.
Scientific journals : Article
Human health sciences : Neurology
http://hdl.handle.net/2268/128005
Effects of light deprivation on visual evoked potentials in migraine without aura.
English
Coppola, Gianluca [> > > >]
Cremers, Julien mailto [Université de Liège - ULg > Département des sciences cliniques > Neurologie]
GERARD, Pascale mailto [Centre Hospitalier Universitaire de Liège - CHU > > Neurologie CHR]
Pierelli, Francesco [> > > >]
Schoenen, Jean mailto [Université de Liège - ULg > Département des sciences biomédicales et précliniques > Neuro-anatomie]
2011
BMC Neurology
BioMed Central
11
91
Yes (verified by ORBi)
International
1471-2377
[en] Adult ; Darkness ; Evoked Potentials, Visual/physiology ; Female ; Habituation, Psychophysiologic/physiology ; Humans ; Male ; Migraine Disorders/physiopathology ; Visual Cortex/physiopathology
[en] BACKGROUND: The mechanisms underlying the interictal habituation deficit of cortical visual evoked potentials (VEP) in migraine are not well understood. Abnormal long-term functional plasticity of the visual cortex may play a role and it can be assessed experimentally by light deprivation (LD). METHODS: We have compared the effects of LD on VEP in migraine patients without aura between attacks (MO, n = 17) and in healthy volunteers (HV, n = 17). Six sequential blocks of 100 averaged VEP at 3.1 Hz were recorded before and after 1 hour of LD. We measured VEP P100 amplitude of the 1st block of 100 sweeps and its change over 5 sequential blocks of 100 responses. RESULTS: In HV, the consequence of LD was a reduction of 1st block VEP amplitude and of the normal habituation pattern. By contrast, in MO patients, the interictal habituation deficit was not significantly modified, although 1st block VEP amplitude, already lower than in HV before LD, further decreased after LD. CONCLUSIONS: Light deprivation is thought to decrease both excitatory and subsequent inhibitory processes in visual cortex, which is in line with our findings in healthy volunteers. The VEP results in migraine patients suggest that early excitation was adequately suppressed, but not the inhibitory mechanisms occurring during long term stimulation and habituation. Accordingly, deficient intracortical inhibition is unlikely to be a primary factor in migraine pathophysiology and the habituation deficit.
http://hdl.handle.net/2268/128005
10.1186/1471-2377-11-91

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