Reference : Phosphorylation of NF-kappa B and I kappa B proteins: implications in cancer and inflamm...
Scientific journals : Letter to the editor
Life sciences : Biochemistry, biophysics & molecular biology
http://hdl.handle.net/2268/1280
Phosphorylation of NF-kappa B and I kappa B proteins: implications in cancer and inflammation
English
Viatour, Patrick [Université de Liège - ULg > > Chimie médicale >]
Merville, Marie-Paule mailto [Université de Liège - ULg > Département de pharmacie > Chimie médicale >]
Bours, Vincent mailto [Université de Liège - ULg > Département des sciences biomédicales et précliniques > Génétique générale et humaine]
Chariot, Alain mailto [Université de Liège - ULg > Département de pharmacie > Chimie médicale >]
Jan-2005
Trends in Biochemical Sciences
Elsevier Science London
30
1
43-52
Yes (verified by ORBi)
International
0968-0004
London
[en] NF-kappa B ; BCL-3 ; phosphorylation
[en] Nuclear factor-kappaB (NF-kappaB) is a transcription factor that has crucial roles in inflammation, immunity, cell proliferation and apoptosis. Activation of NF-kappaB mainly occurs via IkappaB kinase (IKK)-mediated phosphorylation of inhibitory molecules, including IkappaBalpha. Optimal induction of NF-kappaB target genes also requires phosphorylation of NF-kappaB proteins, such as p65, within their transactivation domain by a variety of kinases in response to distinct stimuli. Whether, and how, phosphorylation modulates the function of other NF-kappaB and IkappaB proteins, such as B-cell lymphoma 3, remains unclear. The identification and characterization of all the kinases known to phosphorylate NF-kappaB and IkappaB proteins are described here. Because deregulation of NF-kappaB and IkappaB phosphorylations is a hallmark of chronic inflammatory diseases and cancer, newly designed drugs targeting these constitutively activated signalling pathways represent promising therapeutic tools.
GIGA-R
FNRS, TELEVIE, FBC, ARC ULG
Insight into the oncogenic potential of BCL-3
Researchers ; Professionals ; Students
http://hdl.handle.net/2268/1280
10.1016/j.tibs.2004.11.009

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