Method for the direct elution of reactive 18F fluoride from an anion exchange resin in an organic medium suitable for radiolabeling without any evaporation step by the use of strong organic bases
[fr] PROCÉDÉ POUR L'ÉLUTION DIRECTE DE FLUORURE-18F RÉACTIF À PARTIR D'UNE RÉSINE ÉCHANGEUSE D'ANIONS DANS UN MILIEU ORGANIQUE CONVENANT AU RADIOMARQUAGE SANS AUCUNE ÉTAPE D'ÉVAPORATION À L'AIDE DE BASES ORGANIQUES FORTES
TRASIS S A [BE]; UNIV LIEGE [BE]; LEMAIRE CHRISTIAN [BE]; VOCCIA SAMUEL [BE]; AERTS JOEL [BE]; LUXEN ANDRE [BE]; MORELLE JEAN-LUC [BE]; PHILIPART GAUTHIER [BE
AT , BE , BG , CH , CY , CZ , DE , DK , EE , ES , FI , FR , GB , GR , HR , HU , IE , IS , IT , LI , LT , LU , LV , MC , MT , NL , NO , PL , PT , RO , SE , SI , SK , TR
[en] The present invention relates to a method to extract out of an aqueous solution, concentrate and/or reformulate [18F] fluorides without any evaporation step characterised in that the eluting solution is a organic solution having a water content <3%, containing at least: an organic solvent suitable for the subsequent radiolabelling reaction; a first compound (A) which is a molecule containing at least one acidic hydrogen and a second compound (B) which is an organic base sufficiently strong to be able to tear off the acidic hydrogen of first compound (A) in an acid-base reaction leading to the formation of an organic salt (S).