Reference : Method for the direct elution of reactive 18F fluoride from an anion exchange resin in a...
Patent : Patent
Physical, chemical, mathematical & earth Sciences : Chemistry
http://hdl.handle.net/2268/127998
Method for the direct elution of reactive 18F fluoride from an anion exchange resin in an organic medium suitable for radiolabeling without any evaporation step by the use of strong organic bases
English
[fr] PROCÉDÉ POUR L'ÉLUTION DIRECTE DE FLUORURE-18F RÉACTIF À PARTIR D'UNE RÉSINE ÉCHANGEUSE D'ANIONS DANS UN MILIEU ORGANIQUE CONVENANT AU RADIOMARQUAGE SANS AUCUNE ÉTAPE D'ÉVAPORATION À L'AIDE DE BASES ORGANIQUES FORTES
Lemaire, Christian mailto [Université de Liège - ULg > > Centre de recherches du cyclotron >]
Voccia, Samuel []
Aerts, Joël mailto [Université de Liège - ULg > > Centre de recherches du cyclotron >]
Luxen, André mailto [Université de Liège - ULg > Département de chimie (sciences) > Chimie organique de synthèse >]
Morelle, Jean-luc []
Phillipart, Gauthier []
1-Aug-2009
2008-07-01
OMPI
WO 2009003251
US20070947621P 20070702; EP20070447064 20071120
B
Belgique
TRASIS S A [BE]; UNIV LIEGE [BE]; LEMAIRE CHRISTIAN [BE]; VOCCIA SAMUEL [BE]; AERTS JOEL [BE]; LUXEN ANDRE [BE]; MORELLE JEAN-LUC [BE]; PHILIPART GAUTHIER [BE
B01D15/36
B01D15/36B4
WO
AT , BE , BG , CH , CY , CZ , DE , DK , EE , ES , FI , FR , GB , GR , HR , HU , IE , IS , IT , LI , LT , LU , LV , MC , MT , NL , NO , PL , PT , RO , SE , SI , SK , TR
[en] The present invention relates to a method to extract out of an aqueous solution, concentrate and/or reformulate [18F] fluorides without any evaporation step characterised in that the eluting solution is a organic solution having a water content <3%, containing at least: an organic solvent suitable for the subsequent radiolabelling reaction; a first compound (A) which is a molecule containing at least one acidic hydrogen and a second compound (B) which is an organic base sufficiently strong to be able to tear off the acidic hydrogen of first compound (A) in an acid-base reaction leading to the formation of an organic salt (S).
http://hdl.handle.net/2268/127998

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