ORBi: Lemaire Christian - Method for the direct elution of reactive 18F fluoride from an anion exchange resin in an organic medium suitable for radiolabeling without any evaporation step by the use of strong organic bases

Reference : Method for the direct elution of reactive 18F fluoride from an anion exchange resin in a...


	Document type :	Patent : Patent
	Discipline(s) :	Physical, chemical, mathematical & earth Sciences : Chemistry
	To cite this reference:	http://hdl.handle.net/2268/127998

Title :	Method for the direct elution of reactive 18F fluoride from an anion exchange resin in an organic medium suitable for radiolabeling without any evaporation step by the use of strong organic bases
Language :	English
Alternative title :	[fr] PROCÉDÉ POUR L'ÉLUTION DIRECTE DE FLUORURE-18F RÉACTIF À PARTIR D'UNE RÉSINE ÉCHANGEUSE D'ANIONS DANS UN MILIEU ORGANIQUE CONVENANT AU RADIOMARQUAGE SANS AUCUNE ÉTAPE D'ÉVAPORATION À L'AIDE DE BASES ORGANIQUES FORTES
Author, co-author :	Lemaire, Christian [Université de Liège - ULg > > Centre de recherches du cyclotron >]
	Voccia, Samuel []
	Aerts, Joël [Université de Liège - ULg > > Centre de recherches du cyclotron >]
	Luxen, André [Université de Liège - ULg > Département de chimie (sciences) > Chimie organique de synthèse >]
	Morelle, Jean-luc []
	Phillipart, Gauthier []
Publication date :	1-Aug-2009
Creation date :	2008-07-01
Publisher :	OMPI
Patent/publication number (10-11) :	WO 2009003251
Priority number (30) :	US20070947621P 20070702; EP20070447064 20071120
Report number :	B
Country :	Belgique
Depositor :	TRASIS S A [BE]; UNIV LIEGE [BE]; LEMAIRE CHRISTIAN [BE]; VOCCIA SAMUEL [BE]; AERTS JOEL [BE]; LUXEN ANDRE [BE]; MORELLE JEAN-LUC [BE]; PHILIPART GAUTHIER [BE
International classification (IPC) (51) :	B01D15/36
European classification (ECLA) (52) :	B01D15/36B4
International protection: country codes (81) :	WO
European protection: country codes (84) :	AT , BE , BG , CH , CY , CZ , DE , DK , EE , ES , FI , FR , GB , GR , HR , HU , IE , IS , IT , LI , LT , LU , LV , MC , MT , NL , NO , PL , PT , RO , SE , SI , SK , TR
Abstract :	[en] The present invention relates to a method to extract out of an aqueous solution, concentrate and/or reformulate [18F] fluorides without any evaporation step characterised in that the eluting solution is a organic solution having a water content <3%, containing at least: an organic solvent suitable for the subsequent radiolabelling reaction; a first compound (A) which is a molecule containing at least one acidic hydrogen and a second compound (B) which is an organic base sufficiently strong to be able to tear off the acidic hydrogen of first compound (A) in an acid-base reaction leading to the formation of an organic salt (S).
Permalink :	http://hdl.handle.net/2268/127998

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