Ustekinumab biotherapy and real-time psoriasis capacitance mapping: a pilot study.

[en] In recent years, the treatment of moderate to severe psoriasis has benefited from the development of targeted biologicals. Assessing this new class of drugs calls for precise modalities of severity/improvement ratings of the disease. Bioengineering-driven dermometrology aims at improving objective and quantitative assessments of disease severity and treatment efficacy. Skin capacitance mapping/imaging is one of those emerging methods. Among its clinical applications, psoriasis capacitance mapping (PCM) was introduced in order to assess both skin scaliness and water trapping inside the stratum corneum (inflammatory serum deposits) on lesional skin. PCM was used for assessing the therapeutic effects of ustekinumab on target lesions of 5 psoriatic patients. The reduction in the inflammatory dampness of the stratum corneum was conveniently seen after a 1-month ustekinumab treatment. The present pilot study suggests that PCM could be used as a fast and convenient method for assessing the anti-inflammatory efficacy of ustekinumab and other biotherapies. University Hospital of Liege, 4000 Liege, Belgium.

Disciplines :

Dermatology

Author, co-author :

Franchimont, Claudine ; Université de Liège - ULiège > Département des sciences biomédicales et précliniques > Département des sciences biomédicales et précliniques

PIERARD, Gérald ; Centre Hospitalier Universitaire de Liège - CHU > Dermatopathologie

Language :

English

Title :

Ustekinumab biotherapy and real-time psoriasis capacitance mapping: a pilot study.

Publication date :

2012

Journal title :

Journal of Biomedicine and Biotechnology

ISSN :

1110-7243

eISSN :

1110-7251

Publisher :

Hindawi Publishing Corporation, United States

Volume :

2012

Pages :

870194

Peer reviewed :

Peer Reviewed verified by ORBi

Available on ORBi :

since 23 July 2012

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