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| Reference : Influence of subclinical inflammatory airway disease on equine respiratory function eval... |
| Scientific journals : Article | |||
| Life sciences : Anatomy (cytology, histology, embryology...) & physiology Life sciences : Veterinary medicine & animal health | |||
| http://hdl.handle.net/2268/34703 | |||
| Influence of subclinical inflammatory airway disease on equine respiratory function evalueated by impulse oscillometry | |
| English | |
Richard, Eric  [Frank Duncombe Laboratory > Animal Health > Research and Development > >] | |
| Fortier, Guillaume [Frank Duncombe Laboratory > Animal Health > > Head >] | |
| Denoix, Jean-Marie [> >] | |
| Art, Tatiana [Université de Liège - ULg > Département de sciences fonctionnelles > Phys. neuro-muscul., de l'effort - Méd. sport. des animaux >] | |
| Lekeux, Pierre [Université de Liège - ULg > Département de sciences fonctionnelles > Physiologie - Doyen de la Faculté de Médecine vétérinaire >] | |
| Van Erck, Emmanuelle [> >] | |
| 2009 | |
| Equine Veterinary Journal | |
| Equine Veterinary Journal Ltd | |
| 41 | |
| 4 | |
| 384-389 | |
| International | |
| 0425-1644 | |
| Newmarket Suffolk | |
| United Kingdom | |
| [en] horse ; respiratory function ; forced oscillations ; inflammatory airway disease ; bronchoalveolar lavage | |
| [en] Reasons for performing study: Inflammatory airway disease (IAD) is a nonseptic condition of the lower respiratory tract. Its negative impact on respiratory function has previously
<br /><br />been described using either forced expiration or forced oscillations techniques. However, sedation or drug-induced bronchoconstriction were usually required. The impulse <br /><br />oscillometry system (IOS) is a noninvasive and sensitive respiratory function test validated in horses, which could be useful to evaluate IAD-affected horses without further <br /><br />procedures. <br /><br />Objectives: To determine the sensitivity of IOS in detecting alterations of the respiratory function in subclinically IAD-affected horses without inducing bronchoprovocation and to characterise their respiratory impedance according to frequency for each respiratory phase. <br /><br />Methods: Pulmonary function was evaluated at rest by IOS in 34 Standardbred trotters. According to the cytology of bronchoalveolar lavage fluid (BALF), 19 horses were defined <br /><br />as IAD-affected and 15 horses were used as control (CTL). Total respiratory resistance (Rrs) and reactance (Xrs) from 1–20 Hz as well as their inspiratory and expiratory <br /><br />components were compared between groups. <br /><br />Results: A significant increase of Rrs at the lower frequencies (R1–10 Hz) as well as a significant decrease of Xrs beyond 5 Hz (X5–20 Hz) was observed in IAD compared to CTL horses. IOS-data was also significantly different between inspiration and expiration in IAD-affected horses. In the whole population, both BALF eosinophil and mast cell counts were <br /><br />significantly correlated with IOS measurements. <br /><br />Conclusions: Functional respiratory impairment may be measured, even in the absence of clinical signs of disease. In IAD-affected horses, the different parameters of respiratory <br /><br />function (Rrs or Xrs) may vary depending on the inflammatory cell profiles represented in BALF. <br /><br />Potential relevance: Impulse oscillometry could be used in a routine clinical setting as a noninvasive method for early detection of subclinical respiratory disease and of the results <br /><br />of treatment in horses. | |
| Researchers ; Professionals ; Students | |
| http://hdl.handle.net/2268/34703 | |
| also: http://hdl.handle.net/2268/12774 ; http://hdl.handle.net/2268/12775 | |
| 10.2746/042516409X366121 |
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