Reference : Identification of biochemical reaction networks using a parameter-free coordinate system

	Document type :	Parts of books : Contribution to collective works
	Discipline(s) :	Life sciences : Multidisciplinary, general & others Engineering, computing & technology : Multidisciplinary, general & others
	To cite this reference:	http://hdl.handle.net/2268/12769

Title :	Identification of biochemical reaction networks using a parameter-free coordinate system
Language :	English
Author, co-author :	Fey, Dirk [Université de Liège - ULg > Dép. d'électric., électron. et informat. (Inst.Montefiore) > Méthodes computationnelles pour la biologie systémique >]
	Findeisen, Rolf [> > > >]
	Bullinger, Eric [Université de Liège - ULg > Dép. d'électric., électron. et informat. (Inst.Montefiore) > Méthodes computationnelles pour la biologie systémique >]
Publication date :	Nov-2009
Main document title :	Control-Theoretic Approaches in Systems Biology
Editor :	Iglesias, P. A.
	Ingalls, B.
Publisher :	MIT press
Pages :	293--310
ISBN :	978-0-262-01334-5
Abstract :	[en] A fundamental step in systems biology is the estimation of kinetic parameters, such as association and dissociation constants. Often, their direct estimation from in-vivo studies on isolated reactions is expensive, time-consuming or even infeasible. Therefore, it is necessary to estimate them from indirect measurements, such as time-series data. This chapter proposes an observer-based parameter estimation methodology particularly suited for biochemical reaction networks in which the reaction kinetics are described by polynomial or rational functions. The parameter estimation is performed in three steps. First, the system is transformed into a new set of coordinates in which the system is parameter-free. This facilitates the design of a standard observer in the second step. Finally, the parameter estimates are obtained in a straight-forward way from the observer states, transforming them back to the original coordinates. The approach is illustrated by an example of a MAP kinase signaling pathway.
Permalink :	http://hdl.handle.net/2268/12769

	File(s) associated to this reference
	Fulltext file(s): File Commentary Version Size Access Restricted access mitbook_dfrfeb.pdf Author postprint 769.98 kB Request copy

All documents in ORBi are protected by a user license.

 

© ULg Library Network |  Feedback |  ORBi legal notices

Dspace v1.5