Article (Scientific journals)
Evaluation of chlorine containing cellulose-based chiral stationary phases for the LC enantioseparation of basic pharmaceuticals using polar non-aqueous mobile phases.
Dossou, Katina Sourou Sylvestre; CHIAP, Patrice; Servais, Anne-Catherine et al.
2011In Journal of Separation Science, 34 (6), p. 617-22
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Keywords :
Acidic additive; Discrimination ability; Enantiomers; Polysaccharide-based chiral stationary phases
Abstract :
[en] The discrimination ability of three cellulose-based chiral stationary phases (CSPs) was evaluated towards the enantiomers of basic drugs, using ACN as the main solvent in polar organic mobile phases. The study was focused on CSPs containing cellulose tris(3-chloro-4-methylphenylcarbamate) (3-Cl-4-MePC), cellulose tris(4-chloro-3-methylphenylcarbamate) (4-Cl-3-MePC) or cellulose tris(3,5-dichlorophenylcarbamate) (3,5-diClPC) as the chiral selector. The behaviour of these CSPs was studied systematically in order to investigate the influence of the presence and position of the chlorine substituents on the phenylcarbamate moieties on the retention and resolution of the enantiomers. The evaluation was made with three different generic mobile phases, namely ACN/0.1%DEA/0.1% TFA (DEA, diethylamine), ACN/0.1%DEA/0.2% FA and ACN/0.1%DEA/0.2%AcA, deduced from the previous study. The nature of the acidic additive and of the chiral selector was found to be particularly important for the retention and enantioresolution of these basic compounds. High-resolution values could be obtained for most studied enantiomers with these CSPs, clearly demonstrating the interest of using them in combination with polar organic mobile phases. However, significant differences in enantioresolution between the CSPs have been observed for many compounds, indicating that these phases seem to be quite complementary.
Research center :
CIRM - Centre Interdisciplinaire de Recherche sur le Médicament - ULiège
Disciplines :
Pharmacy, pharmacology & toxicology
Author, co-author :
Dossou, Katina Sourou Sylvestre ;  Université de Liège - ULiège > Doct. sc. bioméd. & pharma. (Bologne)
CHIAP, Patrice ;  Centre Hospitalier Universitaire de Liège - CHU > Pharmacologie clinique
Servais, Anne-Catherine  ;  Université de Liège - ULiège > Département de pharmacie > Analyse des médicaments
Fillet, Marianne ;  Université de Liège - ULiège > Département de pharmacie > Analyse des médicaments
Crommen, Jacques ;  Université de Liège - ULiège > Département de pharmacie > Département de pharmacie
Language :
English
Title :
Evaluation of chlorine containing cellulose-based chiral stationary phases for the LC enantioseparation of basic pharmaceuticals using polar non-aqueous mobile phases.
Publication date :
2011
Journal title :
Journal of Separation Science
ISSN :
1615-9306
eISSN :
1615-9314
Publisher :
Wiley, Weinheim, Germany
Volume :
34
Issue :
6
Pages :
617-22
Peer reviewed :
Peer Reviewed verified by ORBi
Funders :
Alice Seghers Foundation of University of Liege
F.R.S.-FNRS - Fonds de la Recherche Scientifique [BE]
Commentary :
Copyright (c) 2011 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim.
Available on ORBi :
since 16 July 2012

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