Article (Scientific journals)
High intraepithelial expression of estrogen and progesterone receptors in the transformation zone of the uterine cervix
Remoue, Franck; Jacobs, Nathalie; Miot, Valérie et al.
2003In American Journal of Obstetrics and Gynecology, 189 (6), p. 1660-1665
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Keywords :
transformation zone; hormone receptor; uterine cervix; cancer
Abstract :
[en] OBJECTIVE: Because sex hormones may be involved in tumor initiation and progression, we analyzed the presence of hormone receptors in the transformation zone of the uterine cervix where the majority of human papillomavirus infections and associated (pre)neoplastic lesions develop. STUDY DESIGN: By using 23 total hysterectomy samples from young women who underwent surgery for noncervical benign uterine disease, we analyzed, by immunohistologic techniques, the in situ expression of estrogen (E-2-R) and progesterone (P-4-R) receptors in the transformation zone and ectocervix of the same women. RESULTS: The expression of estrogen receptors and progesterone receptors is significantly higher in the transformation zone compared with the ectocervix. Immunohistochemical localization indicated that hormone receptor-positive cells are mainly observed in (para)basal and intermediate cell layers in both the transformation zone and ectocervical epithelium. When transformation zone samples were segregated into epithelial tissues with a predominantly mature (7/23 samples) or immature (16/23 samples) squamous metaplasia, only biopsy specimens with immature squamous metaplasia showed a significantly higher density of hormone receptor-positive cells compared with ectocervical epithelium (P < .01). CONCLUSION: Our results suggest that the cervical transformation zone may be at increased risk of the development of cancer because of a high sensitivity to sex hormone regulation. (Am J Obstet Gynecol 2003; 189:1660-5.)
Disciplines :
Reproductive medicine (gynecology, andrology, obstetrics)
Author, co-author :
Remoue, Franck 
Jacobs, Nathalie   ;  Université de Liège - ULiège > Département des sciences biomédicales et précliniques > Anatomie et cytologie pathologiques
Miot, Valérie
Boniver, Jacques ;  Université de Liège - ULiège > Département des sciences biomédicales et précliniques > Anatomie et cytologie pathologiques
Delvenne, Philippe ;  Université de Liège - ULiège > Département des sciences biomédicales et précliniques > Anatomie et cytologie pathologiques
 These authors have contributed equally to this work.
Language :
English
Title :
High intraepithelial expression of estrogen and progesterone receptors in the transformation zone of the uterine cervix
Publication date :
December 2003
Journal title :
American Journal of Obstetrics and Gynecology
ISSN :
0002-9378
eISSN :
1097-6868
Publisher :
Mosby, Inc, St Louis, United States - Missouri
Volume :
189
Issue :
6
Pages :
1660-1665
Peer reviewed :
Peer Reviewed verified by ORBi
Funders :
F.R.S.-FNRS - Fonds de la Recherche Scientifique [BE]
DGRE - Région wallonne. Direction générale des Relations extérieures [BE]
Commentary :
We thank American Journal of Obstetrics and Gynecology.
Available on ORBi :
since 14 May 2009

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