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| Reference : Differential diagnosis of Alzheimer's disease with PET. |
| Scientific journals : Article | |||
| Human health sciences : Neurology | |||
| http://hdl.handle.net/2268/126984 | |||
| Differential diagnosis of Alzheimer's disease with PET. | |
| English | |
Salmon, Eric  [Université de Liège - ULg > Département des sciences cliniques > Neuroimagerie des troubles de la mémoire et révalid. cogn. >] | |
| Sadzot, Bernard [Université de Liège - ULg > Département des sciences cliniques > Département des sciences cliniques >] | |
| Maquet, Pierre [Université de Liège - ULg > > Centre de recherches du cyclotron >] | |
| Degueldre, Christian [Université de Liège - ULg > > Centre de recherches du cyclotron >] | |
| Lemaire, Christian [Université de Liège - ULg > > Centre de recherches du cyclotron >] | |
| Rigo, Pierre [Université de Liège - ULg > Département des sciences de la motricité > Département des sciences de la motricité >] | |
| Comar, D. [> >] | |
| Franck, G. [> >] | |
| 1994 | |
| Journal of Nuclear Medicine : Official Publication, Society of Nuclear Medicine | |
| 35 | |
| 3 | |
| 391-8 | |
| Yes (verified by ORBi) | |
| 0161-5505 | |
| 1535-5667 | |
| UNITED STATES | |
| [en] Alzheimer Disease/radionuclide imaging ; Brain/metabolism/radionuclide imaging ; Dementia/radionuclide imaging ; Diagnosis, Differential ; Female ; Humans ; Male ; Middle Aged ; Sensitivity and Specificity ; Tomography, Emission-Computed | |
| [en] PET studies have demonstrated bilateral temporo-parietal hypoperfusion and hypometabolism in probable and definite Alzheimer's disease (AD), a pattern that may help differentiate AD from other dementias. METHODS: To evaluate the diagnostic power of cerebral metabolic distribution patterns for "cortical" degenerative dementias, PET scans obtained from 129 patients referred for differential diagnosis of dementia were analyzed visually. RESULTS: Sixty-five patients had a final clinical diagnosis of probable AD. Ninety-seven percent (97%) of those had abnormal metabolic scans and 94% showed a suggestive pattern of bilateral or unilateral temporo-parietal hypometabolism (with or without frontal involvement). Hypometabolism was unilateral in 23% of patients. Five subjects with a neuropathologically proven diagnosis of Alzheimer's disease had a suggestive metabolic pattern. One of those was an early case with frontal hypometabolism exceeding temporo-parietal involvement. Two patients with Alzheimer's-type dementia had isolated bilateral frontal hypometabolism. CONCLUSIONS: This alternative metabolic pattern may correspond to a non-Alzheimer pathology occurring in 10%-20% of patients suffering from clinically probable Alzheimer's disease. Most of the patients with possible but atypical Alzheimer's-type dementia showed isolated bilateral frontal involvement. This metabolic pattern probably corresponds to different diseases, such as Pick's disease, frontal lobe dementia or progressive subcortical gliosis. | |
| http://hdl.handle.net/2268/126984 |
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