Reference : Ligands and tracers for PET studies of the 5-HT system--current status.

	Document type :	Scientific journals : Article
	Discipline(s) :	Physical, chemical, mathematical & earth Sciences : Chemistry
	To cite this reference:	http://hdl.handle.net/2268/126983

Title :	Ligands and tracers for PET studies of the 5-HT system--current status.
Language :	English
Author, co-author :	Crouzel, C. [> >]
	Guillaume, Marcel [Université de Liège - ULg > Département de physique > Spectroscopie atomique et Physique des atomes froids >]
	Barre, L. [> >]
	Lemaire, Christian [Université de Liège - ULg > > Centre de recherches du cyclotron >]
	Pike, V. W. [> >]
Publication date :	1992
Journal title :	International Journal of Radiation Applications and Instrumentation. Part B : Nuclear Medicine and Biology
Volume :	19
Issue/season :	8
Pages :	857-70
Audience :	International
ISSN :	0883-2897
Country :	ENGLAND
Keywords :	[en] Animals ; Humans ; Ligands ; Radioligand Assay ; Receptors, Serotonin/analysis ; Serotonin/metabolism ; Tomography, Emission-Computed
Abstract :	[en] The status of the radiochemical development and biological evaluation of radioligands and tracers for PET studies of the serotonergic system is reviewed, indicating those agents with present value and those with future potential. Practical recommendations are given for the preparation of two useful radioligands for PET studies of central 5-HT2 receptors, namely [18F]setoperone and [18F]altanserin. Though, it has not proved possible to recommend tracers or radioligands for the study of other aspects of serotonergic system, prospects for future radiochemical development are indicated, especially for developing radioligands for the 5-HT re-uptake site, and for the 5-HT1 and 5-HT3 receptors.
Permalink :	http://hdl.handle.net/2268/126983

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