Article (Scientific journals)
Effects of platelet-rich plasma (PRP) on the healing of Achilles tendons of rats
Kaux, Jean-François; Drion, Pierre; Colige, Alain et al.
2012In Wound Repair and Regeneration, 20 (5), p. 748-756
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Keywords :
platelet-rich plasma; Achilles tendon; healing; cryo-jaw; extracellular matrix proteins
Abstract :
[en] Platelet-Rich Plasma (PRP) contains growth factors involved in the tissular healing process. The aim of the study was to determine if an injection of PRP could improve the healing of sectioned Achilles tendons of rats. After surgery, rats received an injection of PRP (n=60) or a physiological solution (n=60) in situ. After 5, 15 and 30 days, 20 rats of both groups were euthanized and 15 collected tendons were submitted to a biomechanical test using cryo-jaws before performing transcriptomic analyses. Histological and biochemical analyses were performed on the 5 remaining tendons in each group. Tendons in the PRP group were more resistant to rupture at 15 and 30 days. The mechanical stress was significantly increased in tendons of the PRP group at day 30. Histological analysis showed a precocious deposition of fibrillar collagen at day 5 confirmed by a biochemical measurement. The expression of tenomodulin was significantly higher at day 5. The mRNA level of type III collage, matrix metalloproteinase 2, 3 and 9 was similar in the 2 groups at all time points whereas type I collagen was significantly increased at day 30 in the PRP group. In conclusion, an injection of PRP in sectioned rat Achilles tendon influences the early phase of tendons healing and results in an ultimate stronger mechanical resistance.
Disciplines :
Orthopedics, rehabilitation & sports medicine
Author, co-author :
Kaux, Jean-François  ;  Université de Liège - ULiège > Département des sciences de la motricité > Département des sciences de la motricité
Drion, Pierre ;  Université de Liège - ULiège > Département des sciences biomédicales et précliniques > GIGA-R:Méth. expér.des anim. de labo et éth. en expér. anim.
Colige, Alain ;  Université de Liège - ULiège > Département des sciences biomédicales et précliniques > Laboratoire des tissus conjonctifs
Pascon, Frédéric
Libertiaux, Vincent
HOFFMANN, Audrey ;  Centre Hospitalier Universitaire de Liège - CHU > Dermatologie
Janssen, Lauriane ;  Université de Liège - ULiège > Département des sciences biomédicales et précliniques > Laboratoire des tissus conjonctifs
HEYERES, Antoine ;  Centre Hospitalier Universitaire de Liège - CHU > Dermatologie
Nusgens, Betty ;  Université de Liège - ULiège > Département des sciences biomédicales et précliniques > Département des sciences biomédicales et précliniques
LE GOFF, Caroline  ;  Centre Hospitalier Universitaire de Liège - CHU > Chimie médicale
Gothot, André ;  Université de Liège - ULiège > Département des sciences cliniques > Département des sciences cliniques
Cescotto, Serge ;  Université de Liège - ULiège > Département ArGEnCo > Département ArGEnCo
Defraigne, Jean-Olivier ;  Université de Liège - ULiège > Département des sciences cliniques > Chirurgie cardio-vasculaire et thoracique
Rickert, Markus
Crielaard, Jean-Michel ;  Université de Liège - ULiège > Département des sciences de la motricité > Evaluation et entraînement des aptitudes physiques
More authors (5 more) Less
Language :
English
Title :
Effects of platelet-rich plasma (PRP) on the healing of Achilles tendons of rats
Publication date :
September 2012
Journal title :
Wound Repair and Regeneration
ISSN :
1067-1927
eISSN :
1524-475X
Publisher :
Blackwell Science, Malden, United States - Massachusetts
Volume :
20
Issue :
5
Pages :
748-756
Peer reviewed :
Peer Reviewed verified by ORBi
Available on ORBi :
since 06 July 2012

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