Reference : Effects of platelet-rich plasma (PRP) on the healing of Achilles tendons of rats
Scientific journals : Article
Human health sciences : Orthopedics, rehabilitation & sports medicine
http://hdl.handle.net/2268/126900
Effects of platelet-rich plasma (PRP) on the healing of Achilles tendons of rats
English
Kaux, Jean-François mailto [Université de Liège - ULg > Département des sciences de la motricité > Département des sciences de la motricité >]
Drion, Pierre mailto [Université de Liège - ULg > Département des sciences biomédicales et précliniques > GIGA-R:Méth. expér.des anim. de labo et éth. en expér. anim. >]
Colige, Alain mailto [Université de Liège - ULg > Département des sciences biomédicales et précliniques > Laboratoire des tissus conjonctifs >]
Pascon, Frédéric [> >]
Libertiaux, Vincent [> >]
HOFFMANN, Audrey [Centre Hospitalier Universitaire de Liège - CHU > > Dermatologie >]
Janssen, Lauriane mailto [Université de Liège - ULg > Département des sciences biomédicales et précliniques > Laboratoire des tissus conjonctifs >]
HEYERES, Antoine [Centre Hospitalier Universitaire de Liège - CHU > > Dermatologie >]
Nusgens, Betty mailto [Université de Liège - ULg > Département des sciences biomédicales et précliniques > Département des sciences biomédicales et précliniques >]
LE GOFF, Caroline mailto [Centre Hospitalier Universitaire de Liège - CHU > > Chimie médicale >]
Gothot, André mailto [Université de Liège - ULg > Département des sciences cliniques > Département des sciences cliniques >]
Cescotto, Serge mailto [Université de Liège - ULg > Département ArGEnCo > Département ArGEnCo >]
Defraigne, Jean-Olivier mailto [Université de Liège - ULg > Département des sciences cliniques > Chirurgie cardio-vasculaire et thoracique >]
Rickert, Markus [> >]
Crielaard, Jean-Michel mailto [Université de Liège - ULg > Département des sciences de la motricité > Evaluation et entraînement des aptitudes physiques >]
Sep-2012
Wound Repair & Regeneration : Official Publication of the Wound Healing Society and the European Tissue Repair Society
Blackwell Science
20
5
748-756
Yes (verified by ORBi)
International
1067-1927
1524-475X
Malden
MA
[en] platelet-rich plasma ; Achilles tendon ; healing ; cryo-jaw ; extracellular matrix proteins
[en] Platelet-Rich Plasma (PRP) contains growth factors involved in the tissular healing process. The aim of the study was to determine if an injection of PRP could improve the healing of sectioned Achilles tendons of rats. After surgery, rats received an injection of PRP (n=60) or a physiological solution (n=60) in situ. After 5, 15 and 30 days, 20 rats of both groups were euthanized and 15 collected tendons were submitted to a biomechanical test using cryo-jaws before performing transcriptomic analyses. Histological and biochemical analyses were performed on the 5 remaining tendons in each group. Tendons in the PRP group were more resistant to rupture at 15 and 30 days. The mechanical stress was significantly increased in tendons of the PRP group at day 30. Histological analysis showed a precocious deposition of fibrillar collagen at day 5 confirmed by a biochemical measurement. The expression of tenomodulin was significantly higher at day 5. The mRNA level of type III collage, matrix metalloproteinase 2, 3 and 9 was similar in the 2 groups at all time points whereas type I collagen was significantly increased at day 30 in the PRP group. In conclusion, an injection of PRP in sectioned rat Achilles tendon influences the early phase of tendons healing and results in an ultimate stronger mechanical resistance.
http://hdl.handle.net/2268/126900
10.1111/j.1524-475X.2012.00826.x

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