Reference : Microtubule targeting agents: from biophysics to proteomics
Scientific journals : Article
Human health sciences : Oncology
http://hdl.handle.net/2268/126805
Microtubule targeting agents: from biophysics to proteomics
English
Calligaris, David [Université de Liège - ULg > Département de chimie (sciences) > GIGA-R : Laboratoire de spectrométrie de masse (L.S.M.) >]
Verdier-Pinard, Pascal [> >]
Devred, François [> >]
Villard, Claude [> >]
Braguer, Diane [> >]
Lafitte, Daniel [> >]
Apr-2010
Cellular and Molecular Life Sciences : CMLS
Birkhäuser
67
7
1089-1104
Yes (verified by ORBi)
International
1420-682X
1420-9071
Basel
Switzerland
[en] This review explores various aspects of the interaction between microtubule targeting agents and tubulin, including binding site, affinity, and drug resistance. Starting with the basics of tubulin polymerization and microtubule targeting agent binding, we then highlight how the three-dimensional structures of drug-tubulin complexes obtained on stabilized tubulin are seeded by precise biological and biophysical data. New avenues opened by thermodynamics analysis, high throughput screening, and proteomics for the molecular pharmacology of these drugs are presented. The amount of data generated by biophysical, proteomic and cellular techniques shed more light onto the microtubule-tubulin equilibrium and tubulin-drug interaction. Combining these approaches provides new insight into the mechanism of action of known microtubule interacting agents and rapid in-depth characterization of next generation molecules targeting the interaction between microtubules and associated modulators of their dynamics. This will facilitate the design of improved and/or alternative chemotherapies targeting the microtubule cytoskeleton.
Researchers ; Professionals ; Students ; General public
http://hdl.handle.net/2268/126805
10.1007/s00018-009-0245-6
http://www.springerlink.com/content/w783gth4pm368120/

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