ORBi: Ait-Belkacem Rima - Mass spectrometry imaging is moving toward drug protein co-localization

Reference : Mass spectrometry imaging is moving toward drug protein co-localization


	Document type :	Scientific journals : Article
	Discipline(s) :	Physical, chemical, mathematical & earth Sciences : Chemistry Human health sciences : Multidisciplinary, general & others Life sciences : Multidisciplinary, general & others
	To cite this reference:	http://hdl.handle.net/2268/126743

Title :	Mass spectrometry imaging is moving toward drug protein co-localization
Language :	English
Author, co-author :	Ait-Belkacem, Rima [Aix-Marseille Université > CRO2, 13385 Marseille, France > INSERM, UMR 911, 13385 Marseille, France > >]
	Sellami, Lyna [Aix-Marseille Université > CRO2, 13385 Marseille, France > INSERM, UMR 911, 13385 Marseille, France > >]
	Villard, Claude [Aix-Marseille Université > CR02, 13385 Marseille, France > INSERM, UMR 911, 13385 Marseille, France > >]
	De Pauw, Edwin [Université de Liège - ULg > Département de chimie (sciences) > GIGA-R : Laboratoire de spectrométrie de masse (L.S.M.) >]
	Calligaris, David [Université de Liège - ULg > Département de chimie (sciences) > GIGA-R : Laboratoire de spectrométrie de masse (L.S.M.) >]
	Lafitte, Daniel [Aix-Marseille Université > CRO2, 13385, Marseille, France > INSERM, UMR 911, 13385 Marseille, France > >]
Publication date :	Sep-2012
Journal title :	Trends in Biotechnology
Publisher :	Elsevier Science
Volume :	30
Issue/season :	9
Pages :	466-474
Audience :	International
ISSN :	0167-7799
City :	Barking
Country :	United Kingdom
Keywords :	[en] Mass Spectrometry ; Imaging
Abstract :	[en] Mass spectrometry (MS)-based technology provides label-free localization of molecules in tissue samples. Drugs, proteins, lipids and metabolites can easily be monitored in their environment. Resolution can be achieved down to the cellular level (10–20 mm) for conventional matrix-assisted laser desorption/ionization (MALDI) imaging, or even to the subcellular level for more complex technologies such as secondary ionization mass spectrometry (SIMS) imaging. One question remains: are we going to be able to investigate functional relationships between drugs and proteins and compare with localized phenomena? This review describes the various spatial levels of investigation offered by mass spectrometry imaging (MSI), and the advantages and disadvantages compared with other labeling technologies.
Research units :	Giga-Systems Biology and Chemical Biology ; CRO2 (Marseille)
Funders :	INSERM ; Fonds de la Recherche Scientifique (Communauté française de Belgique) - F.R.S.-FNRS ; Université de Liège ; Fonds Européen de Développement Régional - FEDER ; Association pour la recherche contre le cancer (ARC) ; Canceropôle PACA ; Conseil regional PACA ; Shimadzu
Target :	Researchers ; Professionals ; Students
Permalink :	http://hdl.handle.net/2268/126743
DOI :	10.1016/j.tibtech.2012.05.006
Other URL :	http://dx.doi.org/10.1016/j.tibtech.2012.05.006

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