Reference : Mass spectrometry imaging is moving toward drug protein co-localization
Scientific journals : Article
Physical, chemical, mathematical & earth Sciences : Chemistry
Human health sciences : Multidisciplinary, general & others
Life sciences : Multidisciplinary, general & others
http://hdl.handle.net/2268/126743
Mass spectrometry imaging is moving toward drug protein co-localization
English
Ait-Belkacem, Rima [Aix-Marseille Université > CRO2, 13385 Marseille, France > INSERM, UMR 911, 13385 Marseille, France > >]
Sellami, Lyna [Aix-Marseille Université > CRO2, 13385 Marseille, France > INSERM, UMR 911, 13385 Marseille, France > >]
Villard, Claude [Aix-Marseille Université > CR02, 13385 Marseille, France > INSERM, UMR 911, 13385 Marseille, France > >]
De Pauw, Edwin mailto [Université de Liège - ULg > Département de chimie (sciences) > GIGA-R : Laboratoire de spectrométrie de masse (L.S.M.) >]
Calligaris, David [Université de Liège - ULg > Département de chimie (sciences) > GIGA-R : Laboratoire de spectrométrie de masse (L.S.M.) >]
Lafitte, Daniel mailto [Aix-Marseille Université > CRO2, 13385, Marseille, France > INSERM, UMR 911, 13385 Marseille, France > >]
Sep-2012
Trends in Biotechnology
Elsevier Science
30
9
466-474
Yes (verified by ORBi)
International
0167-7799
Barking
United Kingdom
[en] Mass Spectrometry ; Imaging
[en] Mass spectrometry (MS)-based technology provides label-free localization of molecules in tissue samples. Drugs, proteins, lipids and metabolites can easily be monitored in their environment. Resolution can be achieved down to the cellular level (10–20 mm) for conventional matrix-assisted laser desorption/ionization (MALDI) imaging, or even to the subcellular level for more complex technologies such as secondary ionization mass spectrometry (SIMS) imaging. One question remains: are we going to be able to investigate functional relationships between drugs and proteins and compare with localized phenomena? This review describes the various spatial levels of investigation offered by mass spectrometry imaging (MSI), and the advantages and disadvantages compared with other labeling technologies.
Giga-Systems Biology and Chemical Biology ; CRO2 (Marseille)
INSERM ; Fonds de la Recherche Scientifique (Communauté française de Belgique) - F.R.S.-FNRS ; Université de Liège ; Fonds Européen de Développement Régional - FEDER ; Association pour la recherche contre le cancer (ARC) ; Canceropôle PACA ; Conseil regional PACA ; Shimadzu
Researchers ; Professionals ; Students
http://hdl.handle.net/2268/126743
10.1016/j.tibtech.2012.05.006
http://dx.doi.org/10.1016/j.tibtech.2012.05.006

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