Reference : Spontaneous neural activity during human slow wave sleep.
Scientific journals : Article
Human health sciences : Neurology
http://hdl.handle.net/2268/1267
Spontaneous neural activity during human slow wave sleep.
English
Dang Vu, Thien Thanh [Université de Liège - ULg > Département des sciences cliniques > Neurologie >]
Schabus, Manuel [Université de Liège - ULg > Centre de Recherches du Cyclotron > Département des sciences cliniques- Psychiatrie et psychologie médicale > >]
Desseilles, Martin mailto [Université de Liège - ULg > Département des sciences cliniques > Psychiatrie et psychologie médicale >]
Albouy, Geneviève [Université de Liège - ULg > > Centre de recherches du cyclotron >]
Boly, Mélanie mailto [Université de Liège - ULg > Département des sciences cliniques > Neurologie >]
Darsaud, Annabelle [Université de Liège - ULG > Centre de Recherches du Cyclotron > > >]
Gais, Steffen [Université de Montréal - UdeM > > > >]
Rauchs, Géraldine [Université de Liège - ULg > Département des sciences cliniques > Neurologie - Doyen de la Faculté de Médecine >]
Sterpenich, Virginie [Université de Liège - ULg > > Centre de recherches du cyclotron >]
Vandewalle, Gilles mailto [Université de Liège - ULg > > Centre de recherches du cyclotron >]
Carrier, Julie [Université de Liège - ULg > Centre de recherches du cyclotron - Département de chimie (sciences) > Chimie organique de synthèse - > >]
Moonen, Gustave mailto [Centre Hospitalier Universitaire de Liège - CHU > > Neurologie Sart Tilman >]
Balteau, Evelyne mailto [Université de Liège - ULg > > Centre de recherches du cyclotron >]
Degueldre, Christian mailto [Université de Liège - ULg > > Centre de recherches du cyclotron >]
Luxen, André mailto [Université de Liège - ULg > Département de chimie (sciences) > Chimie organique de synthèse - Centre de recherches du cyclotron >]
Phillips, Christophe mailto [Université de Liège - ULg > > Centre de recherches du cyclotron - Dép. d'électric., électron. et informat. (Inst.Montefiore) >]
Maquet, Pierre mailto [Centre Hospitalier Universitaire de Liège - CHU > > Neurologie Sart Tilman >]
2008
Proceedings of the National Academy of Sciences of the United States of America
National Academy of Sciences
105
39
15160-5
Yes (verified by ORBi)
International
0027-8424
1091-6490
Washington
DC
[en] Adolescent ; Adult ; Brain/cytology/physiology ; Electroencephalography ; Female ; Humans ; Magnetic Resonance Imaging ; Male ; Neurons/physiology ; Sleep
[en] Slow wave sleep (SWS) is associated with spontaneous brain oscillations that are thought to participate in sleep homeostasis and to support the processing of information related to the experiences of the previous awake period. At the cellular level, during SWS, a slow oscillation (<1 Hz) synchronizes firing patterns in large neuronal populations and is reflected on electroencephalography (EEG) recordings as large-amplitude, low-frequency waves. By using simultaneous EEG and event-related functional magnetic resonance imaging (fMRI), we characterized the transient changes in brain activity consistently associated with slow waves (>140 microV) and delta waves (75-140 microV) during SWS in 14 non-sleep-deprived normal human volunteers. Significant increases in activity were associated with these waves in several cortical areas, including the inferior frontal, medial prefrontal, precuneus, and posterior cingulate areas. Compared with baseline activity, slow waves are associated with significant activity in the parahippocampal gyrus, cerebellum, and brainstem, whereas delta waves are related to frontal responses. No decrease in activity was observed. This study demonstrates that SWS is not a state of brain quiescence, but rather is an active state during which brain activity is consistently synchronized to the slow oscillation in specific cerebral regions. The partial overlap between the response pattern related to SWS waves and the waking default mode network is consistent with the fascinating hypothesis that brain responses synchronized by the slow oscillation restore microwake-like activity patterns that facilitate neuronal interactions.
Centre de Recherches du Cyclotron
Fonds de la Recherche Scientifique (Communauté française de Belgique) - F.R.S.-FNRS ; Fondation Médicale Reine Elisabeth
Researchers ; Professionals ; Students ; General public
http://hdl.handle.net/2268/1267
also: http://hdl.handle.net/2268/7341
10.1073/pnas.0801819105
http://www.pnas.org/content/105/39/15160.abstract

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