Reference : Endotoxin-induced basal respiration alterations of renal HK-2 cells: A sign of pathol...
Scientific journals : Article
Life sciences : Biochemistry, biophysics & molecular biology
Physical, chemical, mathematical & earth Sciences : Multidisciplinary, general & others
http://hdl.handle.net/2268/126696
Endotoxin-induced basal respiration alterations of renal HK-2 cells: A sign of pathologic metabolism down-regulation
English
Quoilin, Caroline mailto [Université de Liège - ULg > Département de physique > Spectroscopie biomédicale >]
Mouithys-Mickalad, Ange mailto [Université de Liège - ULg > > Centre de l'oxygène : Recherche et développement (C.O.R.D.) >]
Duranteau, Jacques mailto []
Gallez, Bernard mailto []
Hoebeke, Maryse mailto [Université de Liège - ULg > Département de physique > Spectroscopie biomédicale >]
Jun-2012
Biochemical and Biophysical Research Communications
Academic Press
423
2
350-354
Yes (verified by ORBi)
International
0006-291X
1090-2104
San Diego
CA
[en] Sepsis ; Inflammation ; Acute kidney injury (AKI) ; Endotoxin ; Oxygen consumption ; Metabolism
[en] To study the mechanism of oxygen regulation in inflammation-induced acute kidney injury, we investigate the effects of a bacterial endotoxin (lipopolysaccharide, LPS) on the basal respiration of proximal tubular epithelial cells (HK-2) both by high-resolution respirometry and electron spin resonance spectroscopy. These two complementary methods have shown that HK-2 cells exhibit a decreased oxygen consumption rate when treated with LPS. Surprisingly, this cellular respiration alteration persists even after the stress factor was removed. We suggested that this irreversible decrease in renal oxygen consumption after LPS challenge is related to a pathologic metabolic down-regulation such as a lack of oxygen utilization by cells.
Fonds de la Recherche Scientifique (Communauté française de Belgique) - F.R.S.-FNRS
Researchers ; Professionals ; General public
http://hdl.handle.net/2268/126696
10.1016/j.bbrc.2012.05.128
http://dx.doi.org/10.1016/j.bbrc.2012.05.128

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