Patent (Patents)
Chitosan-based biomimetic scaffolds and methods for preparing the same
Filée, Patrice; Freichels, Astrid; Jérôme, Christine et al.
2011
 

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Filée P 2011 Patent WO 2011151225 A1.pdf
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Keywords :
biomaterial; scaffold; chitosan; nanofiber; electrospinning
Abstract :
[en] The invention concerns chitosan biomimetic scaffolds and methods for modulating their intrinsic properties such as rigidity, elasticity, resistance to mechanical stress, porosity, biodegradation and absorbance of exudates. Therefore, the present invention relates to a layered chitosan scaffold wherein said layered scaffold comprises at least two fused layers, wherein at least one of the fused layers comprises a chitosan nanofiber membrane and the other fused layer comprises a porous chitosan support layer. Moreover, the present invention provides a layered chitosan scaffold characterized by (i) a good adhesion between the porous and nanofiber layers, (ii) a tuneable porosity of the nanofiber layer by tuning the distance between the nanofibers, (iii) a stable nanofibers and porous morphology even when immersed in water or other solvents and a process for the preparation of such layered chitosan scaffold. Finally, the present invention provides the use of the layered electrospun chitosan scaffold of the invention or the layered electrospun chitosan scaffold produced by the process of the invention as a wound dressing, in tissue engineering or for biomedical applications.
Research center :
Center for Education and Research on Macromolecules (CERM)
Disciplines :
Chemistry
Materials science & engineering
Inventor :
Filée, Patrice
Freichels, Astrid ;  Université de Liège - ULiège
Jérôme, Christine  ;  Université de Liège - ULiège > Department of Chemistry > Center for Education and Research on Macromolecules (CERM)
Aqil, Abdelhafid ;  Université de Liège - ULiège > Department of Chemistry > Center for Education and Research on Macromolecules (CERM)
Colige, Alain ;  Université de Liège - ULiège
Tchemtchoua Tateu, Victor ;  Université de Liège - ULiège
Language :
English
Title (54) :
Chitosan-based biomimetic scaffolds and methods for preparing the same
Publication date (43-45) :
08 December 2011
Filing date (22) :
24 May 2011
Patent/publication number (10-11) :
WO 2011151225
Patent status (13) :
A
Priority number (30) :
EP20100164959 20100604
International classification (IPC) (51) :
A61L15/28; A61L15/42
European classification (ECLA) (52) :
A61L15/28; A61L15/42E; A61L15/64; A61L27/20; A61L27/48; A61L27/56; A61L27/58; A61L27/60
Applicant (71) :
University of Liège (ULg)
Publication organism (19) :
WIPO
Available on ORBi :
since 02 July 2012

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