Patent (Patents)
Chitosan-based biomimetic scaffolds and methods for preparing the same
Filée, Patrick; Freichels, Astrid; Jérôme, Christine et al.
2011
 

Files


Full Text
Filée P 2011 Patent EP 2394670 A1.pdf
Publisher postprint (7.23 MB)
Download

All documents in ORBi are protected by a user license.

Send to



Details



Keywords :
biomaterial; scaffold; chitosan; nanofiber; electrospinning
Abstract :
[en] The invention concerns chitosan-based biomimetic scaffolds and methods for modulating their intrinsic properties such as rigidity, elasticity, resistance to mechanical stress, porosity, biodegradation and absorbance of exudates. Therefore, the present invention relates to a layered chitosan-based scaffold wherein said layered scaffold comprises at least two fused layers, wherein at least one layer consists of a chitosan nanofiber scaffold membrane and at least one of the other layers of a porous chitosan scaffold support layer. Moreover, the present invention provides a layered chitosan-based scaffold characterized by (i) a good adhesion between the porous and nanofiber layers, (ii) a tuneable porosity of the nanofiber layer by tuning the distance between the nanofibers, (iii) a stable nanofibers and porous morphology even when immersed in water or other solvents and a process for the preparation of such layered chitosan-based scaffold.Finally, the present invention provides the use of the layered electrospun chitosan-based scaffold of the invention or the layered electrospun chitosan-based scaffold produced by the process of the invention as a wound dressing, in tissue engineering or for biomedical applications.
Research center :
Center for Education and Research on Macromolecules (CERM)
Disciplines :
Chemistry
Materials science & engineering
Inventor :
Filée, Patrick
Freichels, Astrid ;  Université de Liège - ULiège
Jérôme, Christine  ;  Université de Liège - ULiège > Department of Chemistry > Center for Education and Research on Macromolecules (CERM)
Aqil, Abdelhafid ;  Université de Liège - ULiège > Department of Chemistry > Center for Education and Research on Macromolecules (CERM)
Colige, Alain ;  Université de Liège - ULiège
Tchemtchoua Tateu, Victor ;  Université de Liège - ULiège
Language :
English
Title (54) :
Chitosan-based biomimetic scaffolds and methods for preparing the same
Publication date (43-45) :
14 December 2011
Filing date (22) :
04 June 2010
Patent/publication number (10-11) :
EP 2394670
Patent status (13) :
A
Priority number (30) :
EP20100164959 20100604
International classification (IPC) (51) :
A61L15/28; A61L15/42
European classification (ECLA) (52) :
A61L15/28; A61L15/42E; A61L15/64; A61L27/20; A61L27/48; A61L27/56; A61L27/58; A61L27/60
Applicant (71) :
University of Liège (ULg)
Publication organism (19) :
EPO
Available on ORBi :
since 02 July 2012

Statistics


Number of views
108 (20 by ULiège)
Number of downloads
70 (9 by ULiège)

Bibliography


Similar publications



Contact ORBi