Reference : Seasonal variations in vitamin D levels in melanoma patients: a single-centre prospectiv...
Scientific journals : Article
Human health sciences : Dermatology
Human health sciences : Laboratory medicine & medical technology
http://hdl.handle.net/2268/126581
Seasonal variations in vitamin D levels in melanoma patients: a single-centre prospective pilot comparative study
English
FAILLA, Valérie [Centre Hospitalier Universitaire de Liège - CHU > > Dermatologie >]
CAVALIER, Etienne mailto [Centre Hospitalier Universitaire de Liège - CHU > > Chimie médicale >]
EL HAYDERI, Lara mailto [Centre Hospitalier Universitaire de Liège - CHU > > Dermatologie >]
PAUROBALLY, Dilshad [Centre Hospitalier Universitaire de Liège - CHU > > Dermatologie >]
Chapelle, Jean-Paul mailto [Université de Liège - ULg > Département de pharmacie > Chimie médicale >]
DEZFOULIAN, Bita mailto [Centre Hospitalier Universitaire de Liège - CHU > > Dermatologie >]
NIKKELS, Arjen mailto [Centre Hospitalier Universitaire de Liège - CHU > > Dermatologie >]
May-2012
Journal of the European Academy of Dermatology & Venereology
Blackwell Publishing
26
5
651-3
Yes (verified by ORBi)
International
0926-9959
1468-3083
Oxford
United Kingdom
[en] BACKGROUND: More than 90% of vitamin D synthesis is dependent on UV exposure. Photosensitive disorders such as lupus erythematosus, protoporphyria and xeroderma require strict sun avoidance, and vitamin D deficiency has been demonstrated in these patients. Melanoma patients are also instructed to avoid sun exposure and may hence be expected to be vitamin D deficient.

MATERIALS AND METHODS: Winter and summer vitamin D levels were compared in a group of melanoma patients (n =61) and age- and phototype-matched controls (n = 53) without photosensitive disorders.

RESULTS: Oral supplementary vitamin D intake was reported in 32.7% of the melanoma patients and in 15.1% in the control group. Despite oral supplementation, only 25% of the melanoma patients and the controls presented with vitamin D levels of 30 ng/mL or higher. In non-supplemented subjects in the melanoma and control groups, respectively, mean winter vitamin D levels were below the recommended threshold at 12.6 ng/mL vs. 13.2 ng/mL, respectively, but not statistically different. These values increased significantly in both groups during the summer to 24.6 and 23.8 ng/mL respectively.

CONCLUSION: Unexpected, significant increases in vitamin D levels were seen in melanoma patients during summer, suggesting non-adherence with photoprotective measures and reflecting a heliophilic behaviour. Vitamin D supplementation is recommended in melanoma patients during both winter and summer.
http://hdl.handle.net/2268/126581

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