|Reference : Seasonal variations in vitamin D levels in melanoma patients: a single-centre prospec...|
|Scientific journals : Article|
|Human health sciences : Dermatology|
Human health sciences : Laboratory medicine & medical technology
|Seasonal variations in vitamin D levels in melanoma patients: a single-centre prospective pilot comparative study|
|FAILLA, Valérie [Centre Hospitalier Universitaire de Liège - CHU > > Dermatologie >]|
|CAVALIER, Etienne [Centre Hospitalier Universitaire de Liège - CHU > > Chimie médicale >]|
|EL HAYDERI, Lara [Centre Hospitalier Universitaire de Liège - CHU > > Dermatologie >]|
|PAUROBALLY, Dilshad [Centre Hospitalier Universitaire de Liège - CHU > > Dermatologie >]|
|Chapelle, Jean-Paul [Université de Liège - ULg > Département de pharmacie > Chimie médicale >]|
|DEZFOULIAN, Bita [Centre Hospitalier Universitaire de Liège - CHU > > Dermatologie >]|
|NIKKELS, Arjen [Centre Hospitalier Universitaire de Liège - CHU > > Dermatologie >]|
|Journal of the European Academy of Dermatology & Venereology|
|Yes (verified by ORBi)|
|[en] BACKGROUND: More than 90% of vitamin D synthesis is dependent on UV exposure. Photosensitive disorders such as lupus erythematosus, protoporphyria and xeroderma require strict sun avoidance, and vitamin D deficiency has been demonstrated in these patients. Melanoma patients are also instructed to avoid sun exposure and may hence be expected to be vitamin D deficient.
MATERIALS AND METHODS: Winter and summer vitamin D levels were compared in a group of melanoma patients (n =61) and age- and phototype-matched controls (n = 53) without photosensitive disorders.
RESULTS: Oral supplementary vitamin D intake was reported in 32.7% of the melanoma patients and in 15.1% in the control group. Despite oral supplementation, only 25% of the melanoma patients and the controls presented with vitamin D levels of 30 ng/mL or higher. In non-supplemented subjects in the melanoma and control groups, respectively, mean winter vitamin D levels were below the recommended threshold at 12.6 ng/mL vs. 13.2 ng/mL, respectively, but not statistically different. These values increased significantly in both groups during the summer to 24.6 and 23.8 ng/mL respectively.
CONCLUSION: Unexpected, significant increases in vitamin D levels were seen in melanoma patients during summer, suggesting non-adherence with photoprotective measures and reflecting a heliophilic behaviour. Vitamin D supplementation is recommended in melanoma patients during both winter and summer.
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